1622221-72-0Relevant academic research and scientific papers
Preparation method of indole sulfide compound
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Paragraph 0114-0118, (2019/05/08)
The invention discloses a preparation method of an indole sulfide compound. The preparation method is conducted according to the following steps that a catalyst, an indole reactant, hydrazine hydrate,substituted phenyl sulfonyl chloride and a solvent are
Catalyst-free sulfenylation of indoles with sulfinic esters in ethanol
Yang, Xiuqin,Bao, Yishu,Dai, Zonghao,Zhou, Qingfa,Yang, Fulai
supporting information, p. 3727 - 3731 (2018/08/21)
A novel catalyst-free method for the synthesis of structurally diverse indole thioethers in moderate to excellent yields has been developed. In this reaction, sulfinic esters serve as new sulfur electrophiles.
Photocatalytic direct C-S bond formation: Facile access to 3-sulfenylindoles: Via metal-free C-3 sulfenylation of indoles with thiophenols
Guo, Wei,Tan, Wen,Zhao, Mingming,Tao, Kailiang,Zheng, Lv-Yin,Wu, Yongquan,Chen, Deliang,Fan, Xiao-Lin
, p. 37739 - 37742 (2017/08/18)
An efficient and convenient photocatalytic direct C-3 sulfenylation of indoles with thiophenols has been developed for the construction of 3-sulfenylations. This protocol employs thiophenols as the sulfenylating agents, inexpensive rose bengal as the photocatalyst, and shows mild conditions, readily available starting materials, high atom and step atom economy, and environmental advantages. The representative method provides a straightforward approach for C-S bond formation, and has potential applications in the chemical and pharmaceutical industries.
Preparation method for 3-sulfo-indoles compound
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Paragraph 0139; 0140; 0141; 0142; 0143; 0144; 0145; 0146, (2017/12/27)
The invention relates to the technical field of organic synthesis and provides a preparation method for a 3-sulfo-indoles compound. The 3-sulfo-indoles compound is acquired through the substitution reaction of thiophenols compound and indoles compound under the photo-catalytic effect of photo-catalyst and organic solvent, wherein the photo-catalyst comprises one or more of eosin B, eosin Y and rose bengal. According to the preparation method provided by the invention, the reaction condition is mild, no alkali or oxidizing agent is required, no transition metal catalyst participates into the reaction, the adverse effect of the metal residue to the product performance is effectively avoided, the product performance is promoted, the product yield is increased to 70%, the multi-step synthesis of the reaction raw materials is not required and the technological process is simplified.
Iodine-catalyzed Direct Thiolation of Indoles with Thiols Leading to 3-Thioindoles Using Air as the Oxidant
Liu, Xiaoxia,Cui, Huanhuan,Yang, Daoshan,Dai, Shicui,Zhang, Guoqin,Wei, Wei,Wang, Hua
, p. 1743 - 1748 (2016/08/30)
Abstract: A simple and convenient method has been developed for the construction of 3-thioindoles via molecular iodine-catalyzed direct thiolation of indoles with thiols. The present protocol, which employs thiols as the thiolating agents, inexpensive mol
Iodine-PPh3-mediated C3-sulfenylation of indoles with sodium sulfinates
Katrun, Praewpan,Hongthong, Sakchai,Hlekhlai, Sornsiri,Pohmakotr, Manat,Reutrakul, Vichai,Soorukram, Darunee,Jaipetch, Thaworn,Kuhakarn, Chutima
, p. 18933 - 18938 (2014/05/20)
3-(Alkylsulfanyl)- and 3-(arylsulfanyl)indoles were efficiently prepared by the reaction of indoles with sodium sulfinates mediated by iodine-PPh 3 in ethanol. The salient features of the present protocol are simplicity, high efficiency, non-anhydrous conditions, environmentally friendly reagents and solvent, and short reaction time.
Copper-catalyzed aerobic oxidative N-S bond functionalization for C-S bond formation: Regio- and stereoselective synthesis of sulfones and thioethers
Li, Xianwei,Xu, Yanli,Wu, Wanqing,Jiang, Chang,Qi, Chaorong,Jiang, Huanfeng
supporting information, p. 7911 - 7915 (2014/07/07)
A regio- and stereoselective synthesis of sulfones and thioethers by means of CuI-catalyzed aerobic oxidative N-S bond cleavage of sulfonyl hydrazides, followed by cross-coupling reactions with alkenes and aromatic compounds to form the C-sp-2-S bond, is described herein. N2 and H2O are the byproducts of this transformation, thus offering an environmentally benign process with a wide range of potential applications in organic synthesis and medicinal chemistry. First cleave, then cross-couple: A direct Cu-catalyzed aerobic oxidative C-sp-2-H functionalization and C-S bond coupling reaction has been developed (see scheme). By slight modification of the additive, sulfonyl hydrazides could serve as sulfonation, sulfenation, or arylation reagents to undergo cross-coupling reactions with alkenes and (hetero)aromatic cycles, affording sulfones, thioethers, and biaryl compounds with high regio- and stereoselectivities (see scheme).
