162226-75-7Relevant academic research and scientific papers
Reductive chemistry of the novel hypoxia-selective cytotoxin 5-[N,N- bis(2-chloroethyl)amino]-2,4-dinitrobenzamide
Palmer,Van Zijl,Denny,Wilson
, p. 1229 - 1241 (1995)
5-[N,N-Bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (1; SN 23862) is a novel bioreductive drug whose selective toxicity for hypoxic cells appears due to oxygen-inhibited enzymatic reduction of one of the nitro groups to the corresponding amine or hydroxy
