1622308-28-4

Basic information

• Product Name: 2-bromo-3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide
• Synonyms: 2-bromo-3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide
• CAS NO: 1622308-28-4
• Molecular Weight: 446.116
• Mol File: 1622308-28-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-bromo-3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide(1622308-28-4)
• EPA Substance Registry System: 2-bromo-3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide(1622308-28-4)

Safety Data

• Hazardous Substances Data: 1622308-28-4(Hazardous Substances Data)

Upstream product

• 98733-09-6 6-methoxybenzothiophene-1,1-dioxide 
• 96803-85-9 1-[(2,2-diethoxyethyl)sulfanyl]-3-methoxybenzene 
• 90560-10-4 6-methoxy-benzo[b]thiophene 
• 15570-12-4 3-methoxybenzenethiol 
• 862081-99-0 2,3-dibromo-6-methoxybenzo[b]thiophene 1,1-dioxide 
• 106-41-2 4-bromo-phenol 

Downstream Products

• 1622308-30-8 3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene 1,1-dioxide 
• 1622307-29-2 (E)-3-(4-((2-(4-fluoro-2-(trifluoromethyl)-phenyl)-6-hydroxy-benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid 
• 1622307-20-3 (E)-3-(4-((6-hydroxy-2-(2-(trifluoromethyl)-phenyl)benzo[b]thiophen-3-yl)oxy)phenyl)-acrylic acid 
• 1622307-24-7 (E)-3-(4-((2-(4-fluoro-2-methylphenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)-acrylic acid 
• 1622307-32-7 (E)-3-(4-((2-(2-(tert-butyl)phenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)-acrylic acid 
• 1622307-30-5 (E)-3-(4-((2-(2-ethylphenyl)-6-hydroxybenzo[b]thiophen-3-yl)oxy)phenyl)-acrylic acid 
• 1622307-17-8 (E)-3-(4-((6-hydroxy-2-(o-tolyl)benzo-[b]thiophen-3-yl)oxy)-phenyl)acrylic acid 

Relevant articles and documents

Synthesis Development of the Selective Estrogen Receptor Degrader (SERD) LSZ102 from a Suzuki Coupling to a C-H Activation Strategy

The development of the synthetic process to the selective estrogen receptor degrader (SERD) drug candidate LSZ102 from the medicinal chemistry synthesis to the streamlined large-scale manufacturing route is described. The synthesis of LSZ102 could be sign

COMPOUNDS AND COMPOSITIONS AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS

The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.