1622317-91-2Relevant academic research and scientific papers
Synthetic directions towards capsular polysaccharide of Streptococcus pneumoniae serotype 18C
Karki, Geeta,Kumar Mandal, Pintu
supporting information, (2019/09/17)
An efficient synthetic strategy has been developed for the synthesis of the tri, tetrasaccharide block and pentasaccharide corresponding to the capsular polysaccharide of Streptococcus pneumonia serotype 18C as their 2-aminoethyl glycosides. A one-pot gly
Convergent synthesis and conformational analysis of the hexasaccharide repeating unit of the o-antigen of shigella flexneri serotype 1d
Dhara, Debashis,Kar, Rajiv Kumar,Bhunia, Anirban,Misra, Anup Kumar
, p. 4577 - 4584 (2014/08/05)
A hexasaccharide repeating unit of the O-antigen of the cell wall of Shigella flexneri type 1d has been synthesized using a stereoselective [3+3] block glycosylation approach. Recently developed glycosylation conditions were used in the synthesis. A thioglycoside was used as an orthogonal glycosyl donor during the synthesis. The synthesized hexasaccharide was subjected to detailed NMR spectroscopic and molecular modeling studies to determine its conformational behavior in water. The NOE-based two-dimensional NOSEY experiment and all-atom explicit molecular dynamics (MD) simulation studies suggest that the oligosaccharide is not very flexible, that it remains rigid with respect to the glycosidic linkages between the sugar moieties. Copyright
