1622348-59-7Relevant articles and documents
Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles from Amidoximes and Aldehydes in the Superbasic System NaOH/DMSO
Korsakov, M. K.,Kotov, A. D.,Kunichkina, A. S.,Pankratieva, V. E.,Proskurina, I. K.,Shetnev, A. A.,Vlasov, A. S.
, p. 1181 - 1186 (2020)
Abstract: A new procedure has been proposed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with aldehydes in the superbasic system NaOH/DMSO at room temperature. The scope of the proposed procedure has been demonstrated by 15 syntheses from various amidoximes and aromatic aldehydes with 27–76% yields. The procedure is inapplicable to aliphatic aldehydes.