1622385-33-4Relevant academic research and scientific papers
β-Nitro substituted carboxylic acids and their cytotoxicity
Csuk, René,Heller, Lucie,Siewert, Bianka,Gutnov, Andrey,Seidelmann, Oliver,Wendisch, Volkmar
, p. 4011 - 4013 (2014/09/03)
β-Nitro-substituted ethyl carboxylates are a new class of cytotoxic agents; they can be easily obtained in fair to good yields in a single-step reaction by a Pd-catalyzed asymmetric conjugate addition of aryl boronic acids to 2-nitro-acrylates. Of all the tested derivatives, 2-(4-chlorophenyl)-3- nitropropionic acid ethyl ester (6) is most cytotoxic especially against the human ovarian cancer cell line A2780 therefore making this compound an interesting candidate for further investigations.
