1622426-87-2Relevant academic research and scientific papers
N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases
Otrubova, Katerina,Chatterjee, Shreyosree,Ghimire, Srijana,Cravatt, Benjamin F.,Boger, Dale L.
, p. 1693 - 1703 (2019/03/21)
A series of N-acyl pyrazoles was examined as candidate serine hydrolase inhibitors in which the active site acylating reactivity and the leaving group ability of the pyrazole could be tuned not only through the nature of the acyl group (reactivity: amide
Discovery libraries targeting the major enzyme classes: The serine hydrolases
Otrubova, Katerina,Srinivasan, Venkat,Boger, Dale L.
supporting information, p. 3807 - 3813 (2014/09/16)
Two libraries of modestly reactive ureas containing either electron-deficient acyl anilines or acyl pyrazoles were prepared and are reported as screening libraries for candidate serine hydrolase inhibitors. Within each library is a small but powerful subs
