162254-07-1

Basic information

• Product Name: ((((anthracene-9,10-diylbis(methylene))bis(methylazanediyl))bis(methylene))bis(2,1-phenylene))diboronic acid
• Synonyms: ((((anthracene-9,10-diylbis(methylene))bis(methylazanediyl))bis(methylene))bis(2,1-phenylene))diboronic acid
• CAS NO: 162254-07-1
• Molecular Weight: 532.255
• Mol File: 162254-07-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ((((anthracene-9,10-diylbis(methylene))bis(methylazanediyl))bis(methylene))bis(2,1-phenylene))diboronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: ((((anthracene-9,10-diylbis(methylene))bis(methylazanediyl))bis(methylene))bis(2,1-phenylene))diboronic acid(162254-07-1)
• EPA Substance Registry System: ((((anthracene-9,10-diylbis(methylene))bis(methylazanediyl))bis(methylene))bis(2,1-phenylene))diboronic acid(162254-07-1)

Safety Data

• Hazardous Substances Data: 162254-07-1(Hazardous Substances Data)

Upstream product

• 377780-72-8 2-(2-(bromomethyl)phenyl)-4,4,5,5,-tetramethyl-1,3,2-dioxaborolane 
• 163517-56-4 2-(o-tolyl)-1,3,2-dioxaborinane 
• 16419-60-6 2-Methylphenylboronic acid 
• 7044-91-9 9,10-diformylanthracene 
• 1262488-52-7 C₁₈H₁₆N₂ 
• 166821-90-5 9,10-bis(amino>methyl)anthracene 
• 174900-86-8 propane-1,3-diyl(o-(bromomethyl)phenyl)boronate 

Relevant articles and documents

Noninvasive and Highly Selective Monitoring of Intracellular Glucose via a Two-Step Recognition-Based Nanokit

Accurate determination of intracellular glucose is very important for exploring its chemical and biological functions in metabolism events of living cells. In this paper, we developed a new noninvasive and highly selective nanokit for intracellular glucose monitoring via two-step recognition. The liposome-based nanokit coencapsulated the aptamer-functionalized gold nanoparticles (AuNPs) and the Shinkai's receptor together. When the proposed nanokit was transfected into living cells, the Shinkai's receptor could recognize glucose first and then changed its conformation to endow aptamers with binding and sensing properties which were not readily accessible otherwise. Then, the binary complexes formed by the intracellular glucose and the Shinkai's receptor can in situ displace the complementary oligonucleotide of the aptamer on the surface of AuNPs. The fluorophore-labeled aptamer was away from the AuNPs, and the fluorescent state switched from off to on . Through the secondary identification of aptamer, the selectivity of the Shinkai's receptor could be greatly improved while the intracellular glucose level was assessed by fluorescence signal recovery of aptamer. In the follow-up application, the approach exhibits excellent selectivity and is noninvasive for intracellular glucose monitoring under normoxia and hypoxia. To the best of our knowledge, this is the first time that the advantages of organic receptors and nucleic acids have been combined and highly selective monitoring of intracellular glucose has been realized via two-step recognition. We expect it to open up new possibilities to integrate devices for diagnosis of various metabolic diseases and insulin delivery.

Novel saccharide-photoinduced electron transfer sensors based on the interaction of boronic acid and amine

Two boronic acid systems, monoboronic acid 3 and diboronic acid 8, were synthesized. When saccharides form cyclic boronate esters with these boronic acids, the Lewis acid-base interaction between the boronic acid moiety and tertiary amine is strengthened; when saccharides form cyclic boronate esters with boronic acids the acidity of the boronic acid is enhanced. The strength of this acid-base interaction modulates the photoinduced electron transfer (PET) from the amine to anthracene. Both of these compounds show increased fluoresecence at pH 7.77 through supression of the photoinduced electron transfer from nitrogen to anthracene on saccharide binding, a direct result of the stronger boron-nitrogen bond. Compound 3 shows the typical selectivity of monoboronic acids towards saccharides. Compound 8 which has a cleftlike structure is particularly selective and sensitive for glucose due to the formation of an intramolecular 1:1 complex between the two boronic acids and the 1,2- and 4,6-hydroxyls of glucose. This is the first example in which ditopic recognition of monosaccharides is achieved in a PET sensor system.