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  • (±)- α, α- Diphenyl-1-(phenylmethyl)-2- pyrrolidinemethanol

    Cas No: 16226-60-1

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16226-60-1 Usage

General Description

(±)-1-Benzyl-α,α-diphenyl-2-pyrrolidinemethanol, also known as diphenidine, is a psychoactive chemical compound that belongs to the arylcyclohexylamine class. It is a dissociative anesthetic and NMDA receptor antagonist, and has been used in scientific research to study the effects of NMDA receptor blockade. Diphenidine has been reported to produce hallucinogenic and stimulating effects, and has been sold as a recreational drug in some countries. It is known for its potential for inducing hallucinations and dissociative states, and has been associated with adverse effects such as nausea, vomiting, and cognitive impairment. The long-term effects of diphenidine use are not well understood, and its recreational use is not recommended due to the potential for harm and lack of regulatory oversight.

Check Digit Verification of cas no

The CAS Registry Mumber 16226-60-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,2 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16226-60:
91 % 10 = 1
So 16226-60-1 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name (1-benzylpyrrolidin-2-yl)-diphenylmethanol

1.2 Other means of identification

Product number -
Other names HMS1546M04

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16226-60-1 SDS

16226-60-1Downstream Products

16226-60-1Relevant articles and documents

A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst

Shen, Yongcun,Feng, Xiaoming,Li, Yan,Zhang, Guolin,Jiang, Yaozhong

, p. 5667 - 5675 (2003)

A new family of bifunctional catalysts (N-oxides-Ti(OiPr)4 (2:1)) containing a Lewis acid and a Lewis base was developed and applied to the catalytic cyanosilylation of ketones. Utilizing rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex as catalysts, the cyanosilylation products were obtained in 42-97% yield. Based on experimental phenomena and kinetic studies, a catalytic cycle was proposed to explain the remarkable activities of these catalysts. Investigations indicated that rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex should promote the reaction via a dual activation of the ketone by the titanium and TMSCN by the N-oxide.

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