16226-60-1 Usage
Description
(±)-1-Benzyl-α,α-diphenyl-2-pyrrolidinemethanol, commonly known as diphenidine, is a psychoactive chemical compound belonging to the arylcyclohexylamine class. It functions as a dissociative anesthetic and NMDA receptor antagonist, primarily utilized in scientific research to investigate the impacts of NMDA receptor blockade. Diphenidine is recognized for its potential to induce hallucinations and dissociative states, and it has been reported to elicit both hallucinogenic and stimulating effects. However, its recreational use is cautioned against due to associated adverse effects such as nausea, vomiting, and cognitive impairment, as well as the lack of understanding of its long-term effects and regulatory oversight.
Uses
Used in Scientific Research:
Diphenidine serves as a valuable tool in scientific research, particularly in the study of NMDA receptor blockade and its effects on the central nervous system. It is used as a research chemical for [exploring the mechanisms of action and potential therapeutic applications related to NMDA receptor antagonism].
Used in Recreational Drug Market:
Although not recommended due to potential harm and lack of regulatory oversight, diphenidine has been sold as a recreational drug in some countries. It is used as a psychoactive substance for [producing hallucinogenic and stimulating effects], with users seeking its dissociative and hallucinogenic properties for recreational purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 16226-60-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,2,2 and 6 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 16226-60:
(7*1)+(6*6)+(5*2)+(4*2)+(3*6)+(2*6)+(1*0)=91
91 % 10 = 1
So 16226-60-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H25NO/c26-24(21-13-6-2-7-14-21,22-15-8-3-9-16-22)23-17-10-18-25(23)19-20-11-4-1-5-12-20/h1-9,11-16,23,26H,10,17-19H2
16226-60-1Relevant articles and documents
A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst
Shen, Yongcun,Feng, Xiaoming,Li, Yan,Zhang, Guolin,Jiang, Yaozhong
, p. 5667 - 5675 (2003)
A new family of bifunctional catalysts (N-oxides-Ti(OiPr)4 (2:1)) containing a Lewis acid and a Lewis base was developed and applied to the catalytic cyanosilylation of ketones. Utilizing rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex as catalysts, the cyanosilylation products were obtained in 42-97% yield. Based on experimental phenomena and kinetic studies, a catalytic cycle was proposed to explain the remarkable activities of these catalysts. Investigations indicated that rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex should promote the reaction via a dual activation of the ketone by the titanium and TMSCN by the N-oxide.