201406-78-2

Basic information

• Product Name: Proline, 1-(phenylmethyl)-, methyl ester
• Synonyms: Methyl 1-benzyl-2-pyrrolidinecarboxylate;Methyl 1-benzylprolinate
• CAS NO: 201406-78-2
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol File: 201406-78-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 292.1 °C at 760 mmHg
• Flash Point: 104.8 °C
• Density: 1.12 g/cm³
• CAS DataBase Reference: Proline, 1-(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Proline, 1-(phenylmethyl)-, methyl ester(201406-78-2)
• EPA Substance Registry System: Proline, 1-(phenylmethyl)-, methyl ester(201406-78-2)

Safety Data

• Hazardous Substances Data: 201406-78-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 60169-72-4 1-benzyl-pyrrolidine-2-carboxylic acid 
• 100-52-7 benzaldehyde 
• 43041-12-9 methyl pyrrolidine-2-carboxylate 
• 2133-40-6 methyl pyrrolidine-2-carboxylate hydrochloride 
• 145681-01-2 (+/-)-N-tert-butoxycarbonylproline methyl ester 
• 100-39-0 benzyl bromide 
• 15761-39-4 N-tert-butoxycarbonyl-proline 

Downstream Products

• 16226-60-1 rac-1-benzyl-2-diphenyl(hydroxy)methylpyrrolidine 
• 1353986-84-1 1-benzylpyrrolidine-2-carboxaldehyde 
• 1393836-86-6 (1-benzylpyrrolidin-2-ylmethyl)indan-2-yl-amine 
• 1393836-87-7 (1-benzylpyrrolidin-2-ylmethyl)indan-2-ylphenylamine 
• 1393836-88-8 indan-2-ylphenylpyrrolidin-2-ylmethylamine 
• 1374647-63-8 1-Benzyl-2-ethylpyrrolidine-2-carboxylic acid methyl ester 
• 955029-45-5 (2-methylpyrrolidin-2-yl)methanol 
• 1788873-58-4 methyl 7a-(hydroxymethyl)-2,2-dimethyltetrahydro-1H-pyrrolizin-3(2H)-one 

Relevant articles and documents

Tricyclic dihydroimidazopyrimidinone derivative, and preparation method, pharmaceutical composition and application thereof

The invention provides a compound as shown in a general formula (I), cis-trans isomers, enantiomers, diastereoisomers, racemes, solvates, hydrates or pharmaceutically acceptable salts or prodrugs of the compound, a preparation method of the compound, a pharmaceutical composition containing the compound and an application of the compound as aLp-PLA2 inhibitor, wherein R1, R2, Rx, Ra, Q, U, X, Y, m, n and A are defined in the specification.

Aminoindane Compounds and Use Thereof in Treating Pain

The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.

A mild and efficient cyanosilylation of ketones catalyzed by a Lewis acid-Lewis base bifunctional catalyst

A new family of bifunctional catalysts (N-oxides-Ti(OiPr)4 (2:1)) containing a Lewis acid and a Lewis base was developed and applied to the catalytic cyanosilylation of ketones. Utilizing rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex as catalysts, the cyanosilylation products were obtained in 42-97% yield. Based on experimental phenomena and kinetic studies, a catalytic cycle was proposed to explain the remarkable activities of these catalysts. Investigations indicated that rac((1R,2S) and (1S,2R))-1-(2′-pyridylmethyl)-2-diphenylhydroxymethylpyrrolidine N-oxide-titanium (2:1) complex and N-benzyl-diethanolamine N-oxide-titanium (2:1) complex should promote the reaction via a dual activation of the ketone by the titanium and TMSCN by the N-oxide.