162272-90-4

Basic information

• Product Name: 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol
• Synonyms: 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol
• CAS NO: 162272-90-4
• Molecular Weight: 375.695
• Mol File: 162272-90-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol(162272-90-4)
• EPA Substance Registry System: 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol(162272-90-4)

Safety Data

• Hazardous Substances Data: 162272-90-4(Hazardous Substances Data)

Upstream product

• 110977-90-7 6-Brom-4,9-dihydropyrano<3,4-b>indol-1(3H)-on 
• 104-86-9 4-chlorobenzylamine 
• 162272-84-6 6-Brom-2-(4-chlorbenzyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indol-1-on 

Downstream Products

• 59444-69-8 6-Brom-9H-pyrido<3,4-b>indol 
• 244-63-3 betacarboline 

Relevant articles and documents

Indoles, XII: β-Carbolines from lactones - Synthesis of ligands of the norharmane receptor

Starting from α-ethoxalyl-δ-valerolactone (1) 6-substituted β-carbolines were synthesized in 5 steps to enable investigations at the norharmane binding sites in rat liver and in pig brain. The Pd-catalyzed aromatization of N-benzyl-tetrahydro-β-carbolines with debenzylation was optimized with 5a → 6a and then used for the preparation of other derivatives. Additional hydrogenolyses occur with 5d,h. Bromination of 1a gives 6d which can be transferred to the radioligand 3H-norharmane.