1622867-06-4

Basic information

• Product Name: C₂₇H₂₆N₄O₄S
• Synonyms: C₂₇H₂₆N₄O₄S
• CAS NO: 1622867-06-4
• Molecular Weight: 502.594
• Mol File: 1622867-06-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₇H₂₆N₄O₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₇H₂₆N₄O₄S(1622867-06-4)
• EPA Substance Registry System: C₂₇H₂₆N₄O₄S(1622867-06-4)

Safety Data

• Hazardous Substances Data: 1622867-06-4(Hazardous Substances Data)

Upstream product

• 1327699-52-4 C₁₈H₂₆N₂O₄ 
• 119-67-5 o-carboxybenzaldehyde 
• 61260-15-9 dimethyl (3-oxo-1,3-dihydroisobenzofuran-1-yl)phosphonate 
• 1622867-34-8 C₁₄H₁₀N₂O₃S 
• 119784-75-7 2-(4-methoxyphenyl)-1-(piperazin-1-yl)ethanone 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 51770-04-8 4-cyano-2-thiophenecarboxaldehyde 
• 104-01-8 4-Methoxyphenylacetic acid 

Relevant articles and documents

Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors

We have developed a series of substituted 4-(thiophen-2-ylmethyl)-2H- phthalazin-1-ones as potent PARP-1 inhibitors. Preliminary biological evaluation indicated that most compounds possessed inhibitory potencies comparable to, or higher than AZD-2281. Among these compounds, 18q appeared to be the most notable one, which displayed an 8-fold improvement in enzymatic activity compared to AZD-2281. These efforts lay the foundation for our further investigation.