119784-75-7

Usage

Category

Ketones and piperazine derivatives

Structural motif

Piperazine ring

Presence of functional groups

Methoxyphenyl group

Potential

Pharmacological or biological activities

Need for further research

To determine specific properties and applications

Industry interest

Pharmaceutical and chemical industries

Upstream product

• 110-85-0 piperazine 
• 123331-31-7 1-(1H-imidazol-1-yl)-2-(4-methoxyphenyl)ethan-1-one 
• 142-64-3 piperazine dihydrochloride 
• 104-01-8 4-Methoxyphenylacetic acid 
• 1327699-52-4 C₁₈H₂₆N₂O₄ 

Downstream Products

• 1622867-06-4 C₂₇H₂₆N₄O₄S 

Relevant academic research and scientific papers

Oxazolo[4,5-b]pyridine-Based Piperazinamides as GSK-3β Inhibitors with Potential for Attenuating Inflammation and Suppression of Pro-Inflammatory Mediators

Recent studies reveal that glycogen synthase kinase-3β (GSK-3β) acts as a pro-inflammatory enzyme, and by inhibiting this kinase, inflammation can be controlled. In this regard, a series of 17 piperazine-linked oxazolo[4,5-b]pyridine-based derivatives was

Synthesis and biological evaluation of substituted 4-(thiophen-2-ylmethyl)- 2H-phthalazin-1-ones as potent PARP-1 inhibitors

We have developed a series of substituted 4-(thiophen-2-ylmethyl)-2H- phthalazin-1-ones as potent PARP-1 inhibitors. Preliminary biological evaluation indicated that most compounds possessed inhibitory potencies comparable to, or higher than AZD-2281. Among these compounds, 18q appeared to be the most notable one, which displayed an 8-fold improvement in enzymatic activity compared to AZD-2281. These efforts lay the foundation for our further investigation.

CDI-mediated monoacylation of symmetrical diamines and selective acylation of primary amines of unsymmetrical diamines

A highly efficient and green protocol for monoacylation of symmetrical diamines and chemoselective acylation of primary amines of unsymmetrical diamines has been developed.