1622872-55-2Relevant articles and documents
Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists
Tanaka, Yuta,Gamo, Kanae,Oyama, Takuji,Ohashi, Masao,Waki, Minoru,Matsuno, Kenji,Matsuura, Nobuyasu,Tokiwa, Hiroaki,Miyachi, Hiroyuki
, p. 4001 - 4005 (2014/09/17)
We previously reported that a α-benzylphenylpropanoic acid-type hPPARγ-selective agonist with a piperidine ring as the hydrophobic tail part (3) exhibited sub-micromolar-order hPPARγ agonistic activity. In order to enhance the activity, we planned to carr