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CAS

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1622878-72-1

C19H14BrN3O2 is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1622878-72-1 Structure

  • Basic information

    1. Product Name: C19H14BrN3O2
    2. Synonyms: C19H14BrN3O2
    3. CAS NO:1622878-72-1
    4. Molecular Formula:
    5. Molecular Weight: 396.243
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1622878-72-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: C19H14BrN3O2(CAS DataBase Reference)
    10. NIST Chemistry Reference: C19H14BrN3O2(1622878-72-1)
    11. EPA Substance Registry System: C19H14BrN3O2(1622878-72-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1622878-72-1(Hazardous Substances Data)

1622878-72-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1622878-72-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,2,8,7 and 8 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1622878-72:
(9*1)+(8*6)+(7*2)+(6*2)+(5*8)+(4*7)+(3*8)+(2*7)+(1*2)=191
191 % 10 = 1
So 1622878-72-1 is a valid CAS Registry Number.

1622878-72-1Downstream Products

1622878-72-1Relevant articles and documents

Chalcone based azacarboline analogues as novel antitubulin agents: Design, synthesis, biological evaluation and molecular modelling studies

Sharma, Sahil,Kaur, Charanjit,Budhiraja, Abhishek,Nepali, Kunal,Gupta, Manish K.,Saxena,Bedi

, p. 648 - 660 (2014/09/17)

The present study involves the design of a series of 3-aryl-9-acetyl- pyridazino[3,4-b]indoles as constrained chalcone analogues. A retrosynthetic route was proposed for the synthesis of target compounds. All the synthesized compounds were evaluated for in-vitro cytotoxicity against THP-1, COLO-205, HCT-116 and A-549 human cancer cell lines. The results indicated that 2a, 3a, 5a and 6a possessed significant cytotoxic potential with an IC50 value ranging from 1.13 to 5.76 μM. Structure activity relationship revealed that the nature of both Ring A and Ring B influences the activity. Substitution of methoxy groups on the phenyl ring (Ring A) and unsubstituted phenyl ring (Ring B) were found to be the preferred structural features. The most potent compound 2a was further tested for tubulin inhibition. Compound 2a was found to significantly inhibit the tubulin polymerization (IC50 value - 2.41 μM against THP-1). Compound 2a also caused disruption of microtubule assembly as evidenced by Immunoflourescence technique. The significant cytotoxicity and tubulin inhibition by 2a was rationalized by molecular modelling studies. The most potent structure was docked at colchicine binding site (PDB ID-1SA0) and was found to be stabilized in the cavity via various hydrophobic and hydrogen bonding interactions.

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