1622982-21-1

Basic information

• Product Name: C₁₅H₉FN₄OS
• CAS NO: 1622982-21-1
• Molecular Weight: 312.327
• Mol File: 1622982-21-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₉FN₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₉FN₄OS(1622982-21-1)
• EPA Substance Registry System: C₁₅H₉FN₄OS(1622982-21-1)

Safety Data

• Hazardous Substances Data: 1622982-21-1(Hazardous Substances Data)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 52505-45-0 1,2-dihydro-2-thioxopyridine-3-carbonitrile 
• 350672-14-9 2-(chloromethyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole 

Downstream Products

• 1622982-11-9 C₁₅H₇BrFN₃OS 
• 1622981-98-9 C₂₁H₁₁ClFN₃OS 

Relevant articles and documents

Thieno[2,3-b]pyridines as negative allosteric modulators of metabotropic GluR5 receptors: Hit-to-lead optimization

An HTS campaign of our corporate compound library resulted in thieno[2,3-b]pyridines derivative hits with mGluR5 negative allosteric modulator effects. During the hit-to-lead development our objective was to improve affinity, and to keep the ligand efficiency values at an acceptable level. After different modifications of the linker resulted in a 2-sulfonyl-thieno[2,3-b] pyridines derivative, which fulfilled the lead criteria.