162334-32-9

Upstream product

• 51674-10-3 N,N-diethyl-2-methoxybenzamide 
• 579-75-9 2-Methoxybenzoic acid 

Downstream Products

• 1137963-64-4 C₁₉H₃₀N₄O₃ 
• 1360789-53-2 methyl 2-hydroxy-6-iodobenzoate 
• 1383707-74-1 (E)-benzyl 2-[4-(benzyloxy)isobenzofuran-1(3H)-ylidene]acetate 
• 1383707-73-0 (Z)-benzyl 2-[4-(benzyloxy)isobenzofuran-1(3H)-ylidene]acetate 
• 1383707-90-1 N,N-diethyl-2-hydroxy-6-iodobenzamide 
• 1383707-91-2 methyl 2-(benzyloxy)-6-iodobenzoate 
• 1383707-35-4 [2-(benzyloxy)-6-iodophenyl]methanol 
• 66820-34-6 isoochracinic acid 

Relevant academic research and scientific papers

Phosphine/palladium-catalyzed syntheses of alkylidene phthalans, 3-deoxyisoochracinic acid, isoochracinic acid, and isoochracinol

In this study we used sequential catalysis-PPh3-catalyzed nucleophilic addition followed by Pd(0)-catalyzed Heck cyclization-to construct complex functionalized alkylidene phthalans rapidly, in high yields, and with good stereoselectivities (E/Z ratios of up to 1:22). The scope of this Michael-Heck reaction includes substrates bearing various substituents around the alkylidene phthalan backbone. Applying this efficient sequential catalysis, we accomplished concise total syntheses of 3-deoxyisoochacinic acid, isoochracinic acid, and isoochracinol.

Ortho-metalated aromatic tertiary amides: New synthetic applications

Ortho-lithio-cuprate species derived from aromatic tertiary amides exhibited a significantly larger field of application than the lithio precursor.