51674-10-3

Usage

Uses

Used in Pharmaceutical Industry:
N,N-Diethyl-2-methoxy-benzamide is used as an intermediate in the production of pharmaceuticals for its versatile chemical properties and potential applications in drug development.
Used as a Topical Analgesic and Anti-Inflammatory Agent:
In the healthcare industry, N,N-Diethyl-2-methoxy-benzamide is utilized as a topical analgesic and anti-inflammatory agent, providing relief from pain and reducing inflammation.
Used as an Insect Repellent:
N,N-Diethyl-2-methoxy-benzamide, known by the trade name DEET, is widely used as an insect repellent in various commercial products. It is effective in repelling insects and is a key component in insect repellent sprays, lotions, and other formulations to protect against insect-borne diseases.

InChI:InChI=1/C12H17NO2/c1-4-13(5-2)12(14)10-8-6-7-9-11(10)15-3/h6-9H,4-5H2,1-3H3

Upstream product

• 19311-91-2 N,N-diethylsalicylamide 
• 77-78-1 dimethyl sulfate 
• 579-75-9 2-Methoxybenzoic acid 
• 109-89-7 diethylamine 
• 529-28-2 4-iodoanisol 
• 201230-82-2 carbon monoxide 
• 121-44-8 triethylamine 
• 578-57-4 2-bromoanisole 
• 1441-87-8 salicyloyl chloride 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 335343-05-0 5,5-dimethyl-2-(2-methoxyphenyl)-[1,3,2]dioxaborinane 
• 36598-12-6 bis(N,N-diethylcarbamoyl) diselenide 
• 100-66-3 methoxybenzene 
• 21615-34-9 2-Methoxybenzoyl chloride 

Downstream Products

• 92242-85-8 6-(2-acetoxyethyl)-6-<(N,N-diethylamino)carbonyl>-1-methoxy-1,4-cyclohexadiene 
• 88440-84-0 N,N-Diethyl-2-allyl-6-methoxybenzamide 
• 70946-23-5 2-[(2,5-Dimethoxy-4-methyl-phenyl)-hydroxy-methyl]-N,N-diethyl-6-methoxy-benzamide 
• 180198-99-6 N,N-Diethyl-2-(4-hydroxy-pentanoyl)-6-methoxy-benzamide 
• 133730-22-0 3-methoxy-2-(N,N-diethylcarboxamido)phenylboronic acid 
• 834-99-1 1-methoxyphenanthrene 
• 132858-49-2 1-(3-hydroxyphenyl)-1-heptanone 
• 334698-83-8 N,N-diethyl-2-heptanoyl-6-methoxybenzamide 
• 334698-82-7 (+/-)-N,N-diethyl-2-(1-hydroxyheptyl)-6-methoxybenzamide 
• 111540-00-2 ochromycinone 
• 96239-80-4 2-Methoxy-6-(6-methyl-5,6-dihydro-naphthalen-1-ylmethyl)-benzoic acid 
• 111539-96-9 2-Methoxy-6-(6-methyl-8-oxo-5,6,7,8-tetrahydro-naphthalen-1-ylmethyl)-benzoic acid 
• 111539-90-3 N,N-Diethyl-2-[hydroxy-((6R,8R)-8-hydroxy-6-methyl-5,6,7,8-tetrahydro-naphthalen-1-yl)-methyl]-6-methoxy-benzamide 
• 96239-81-5 (1S,2S)-1-Hydroxy-8-methoxy-3-methyl-2-phenylselanyl-1,2,3,4-tetrahydro-benzo[a]anthracene-7,12-dione 

Relevant academic research and scientific papers

BISCARBAMOYL DISELENIDES AS NEW CARBAMOYLATING REAGENTS. LEWIS ACID PROMOTED CARBAMOYLATION OF AROMATIC COMPOUNDS

The reaction of biscarbamoyl diselenides with aromatic compounds in the presence of Lewis acids resulted in Friedel-Crafts type carbamoylation (Gatterman amide synthesis) to give corresponding aromatic amides in good yields.This methodology was successfully applied to aroylation and benzylation by use of dibenzoyl diselenide and dibenzyl diselenide, respectively.

Selective Oxidative Dearomatization of Angular Tetracyclic Phenols by Controlled Irradiation under Air: Synthesis of an Angucyclinone-Type Double Peroxide with Anticancer Properties

Angular tetracyclic p-peroxyquinols, p-quinols, and a pentacyclic double peroxide, showing anticancer properties, were synthesized from the corresponding phenols by an environmentally friendly solvent- and wavelength-controlled irradiation under air in th

Pd-Catalyst Containing a Hemilabile P,C-Hybrid Ligand in Amino Dicarbonylation of Aryl Halides for Synthesis of α-Ketoamides

The amino dicarbonylation of aryl halides affording α-ketoamides with Pd catalysts is highly dependent on the stereoelectronic properties of the involved ligands. Ionic diphosphine ligand L4 can serve as precursor of a hemilabile P,C (phosphine, carbene)-hybrid ligand to form a stable Pd(II)-complex, Pd-L4. In contrast, analogues L1-L3 with a similar 1-(thiophen-3-yl)-benzimidazolyl skeleton behave as typical (mono/di)phosphines. The catalytic system resulting from the complexation of PdCl2(MeCN)2 and L4 exhibits good catalytic performance in terms of aryl iodides conversion (81-95%) and α-ketoamide selectivity (80-91%), as well as the available recyclability in the RTIL of [Bpy]BF4. The in situ FT-IR analysis reveals that the PdCl2(MeCN)2-L4 catalytic system favors the amino dicarbonylation toward α-ketoamides according to the proposed mechanism of cycle I, which involves two independent CO-insertion steps.

Inhibitors of protein activity for the treatment of angiogenesis and SOX18/or lymphangiogenesis-related diseases

Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiog

INHIBITORS OF SOX18 PROTEIN ACTIVITY FOR TREATING ANGIOGENESIS-AND/OR LYMPHANGIOGENESIS-RELATED DISEASES

Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiog

AMIDATION METHOD AND ESTERIFICATION METHOD USING SULFONIC ACID HALIDE

PROBLEM TO BE SOLVED: To provide a safe and economical method for rapidly synthesizing amides and esters in high yield. SOLUTION: There is provided a method for amidating an amine or a derivative thereof using a sulfonic acid halide, where a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an amine or a derivative thereof as a nucleophile to amidate the amine or the derivative thereof to obtain a corresponding amide or a derivative thereof. In a similar manner, a sulfonic acid halide is allowed to act as an activator on a carboxylic acid or a derivative thereof to synthesize an active ester, and the active ester is reacted with an alcohol or a derivative thereof as a nucleophile to esterify the alcohol or the derivative thereof to obtain a corresponding ester or a derivative thereof. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPO&INPIT

Pd/C-catalyzed aminocarbonylation of aryl iodides via oxidative C-N bond activation of tertiary amines to tertiary amides

This work reports oxidative N-dealkylation/carbonylation of tertiary amines to tertiary amides by using molecular oxygen as a sole oxidant using a Pd/C catalyst. This protocol is free from ligands, additives, bases, and cocatalysts. Different tertiary amines as well as aryl iodides have been examined for this transformation, providing desired products in good to excellent yield.

Directed Metalation-Suzuki-Miyaura Cross-Coupling Strategies: Regioselective Synthesis of Hydroxylated 1-Methyl-phenanthrenes

A general, efficient, and regioselective synthesis of a series of hydroxylated 1-methylphenanthrenes 9 by a combined directed ortho metalation (DoM)-Suzuki-Miyaura cross-coupling-directed remote metalation (DreM) sequence is reported. Diversity to this methodology was achieved by a regioselective DoM rather than DreM reaction, affording more highly substituted phenanthrols (Table 2). Application of the turbo-Grignard reagent (i-PrMgCl·LiCl) in the Ni-catalyzed Corriu-Kumada reaction gave efficient decarbamoylation (Tables 3and 4). Additional features are the TMS protecting group and halo-induced ipso-desilylation tactics applied to the regioselective synthesis of phenanthrenes (Scheme 2).

Photostability of 4,4′-dihydroxythioindigo, a mimetic of indigo

The photochemical properties of indigo, a widely used industrial dye, has attracted both experimentalists and theoreticians from the beginning. Especially the high photostability of indigo has been the subject of intensive research. Recently, it was propo

A practical in situ generation of the schwartz reagent. reduction of tertiary amides to aldehydes and hydrozirconation

A new, highly efficient in situ protocol (Cp2ZrCl2/LiAlH(OBu-t)3) is described for the generation of the Schwartz reagent which provides a convenient method for the amide to aldehyde reduction and the regioselective hydrozirconation-iodination of alkynes and alkenes. Highlighted are chemoselective reductions of benzamides derived by directed ortho metalation (DoM) chemistry, allowing the synthesis of valuable 1,2,3-substituted benzaldehydes. The single-step, three-component process proceeds in a very short reaction time, shows excellent functional group compatibility, and uses inexpensive and long-storage stable reducing reagents.