162356-89-0

Basic information

• Product Name: [4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid
• Synonyms: [4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid;4-TBSMS-hydroxymethylphenylboronic acid;[4-[[[tert-Butyl)dimethylsilyl]oxy]methyl]phenylboronic acid;4-TBDMSO-methylphenylboronic acid;Boronic acid, B-[4-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]phenyl]-
• CAS NO: 162356-89-0
• Molecular Formula: C₁₃H₂₃BO₃Si
• Molecular Weight: 266.219
• Mol File: 162356-89-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 153-155°C
• Boiling Point: 356.1±44.0 °C(Predicted)
• Appearance: /
• Density: 1.00±0.1 g/cm3(Predicted)
• Refractive Index: 1.509
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 8.53±0.16(Predicted)
• CAS DataBase Reference: [4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid(162356-89-0)
• EPA Substance Registry System: [4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid(162356-89-0)

Safety Data

• Hazardous Substances Data: 162356-89-0(Hazardous Substances Data)

Usage

General Description

[4-[[[1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenylboronic Acid is a chemical compound with the molecular formula C14H25BO3Si. It is a boronic acid derivative with a phenyl group and a silyl-protected alcohol functional group. This chemical is often used as a reagent in organic synthesis, particularly for the formation of carbon-carbon bonds through Suzuki coupling reactions. The silyl-protected alcohol group makes it a valuable building block in the synthesis of complex organic molecules. Additionally, its boronic acid functionality allows it to participate in a wide range of reactions, making it a versatile and useful compound in the field of organic chemistry.

InChI:InChI=1/C13H23BO3Si/c1-13(2,3)18(4,5)11-6-7-12(14(16)17)10(8-11)9-15/h6-8,15-17H,9H2,1-5H3

Upstream product

• 1072960-69-0 (C(CH₃)3Si(CH₃)2OCH₂C₆H₄)BN(CH₃)(CH₂CO₂)2 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 873-75-6 4-bromobenzenemethanol 
• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 

Downstream Products

• 477338-82-2 2-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-4,5-dimethyl-[1,3,2]dioxaborolane 
• 1204190-96-4 C₈-(4-(TBS-O-methyl)phenyl)-2'-deoxyguanosine 
• 1613027-65-8 2-(4-(((tert-butyldimethylsilyl)oxy)methyl)phenyl)pyridine 
• 1613027-79-4 tert-butyl [5-(tert-butyldimethylsilyloxymethyl)-2-(pyridin-2-yl)phenyl]carbamate 
• 648424-24-2 [1,1-dimethyl-2-oxo-2-[[(3R)-2,3,4,5-tetrahydro-1-[[2'-[[[(methylamino)carbonyl]amino]methyl][1,1'-biphenyl]-4-yl]methyl]-2-oxo-1H-1-benzazepin-3-yl]amino]ethyl]carbamic acid (1,1-dimethylethyl) ester 
• 198205-99-1 2'-(aminomethyl)[1,1'-biphenyl]-4-methanol 
• 637004-43-4 ClCOOCH₂C₆H₄BO₂C₄H₈ 
• 637004-42-3 2-(4-hydroxymethyl-phenyl)-4,5-dimethyl-[1,3,2]dioxaborolane 

Relevant articles and documents

A comparison of shuttling mechanisms in two constitutionally isomeric bistable rotaxane-based sunlight-powered nanomotors

To find out how best to optimize shuttling of the macrocycle in a particular class of photochemically driven molecular abacus, which has the molecular structure of BR-I6+ in its Mark I prototype (Ashton et al., Chem. Eur. J. 2000, 6, 3558), we

A convergent asymmetric synthesis of a growth hormone secretagogue

Described herein is a convergent asymmetric synthesis of growth hormone secretagogue (GHS) suitable for large-scale preparations. Key features include: (1) an improved method for α-iodination of a lactam; (2) a novel synthesis of a disubstituted urea usin

Benzo-fused lactams promote release of growth hormone

There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. The compounds are prepared by substitution of an amino-lactam with a substituted amide function. Growth promoting compositions containing such bezno-fused lactams as the active ingredient thereof are also disclosed. STR1 where L is STR2