162405-05-2Relevant articles and documents
Visible-Light-Induced Decarboxylative Cyclization/Hydrogenation Cascade Reaction to Access Phenanthridin-6-yl(aryl)methanol by an Electron Donor-Acceptor Complex
Shi, Wei,Ma, Fang,Li, Pinhua,Wang, Lei,Miao, Tao
, p. 13808 - 13817 (2020)
A novel and efficient visible-light-induced decarboxylative cyclization/hydrogenation cascade reaction of α-oxocarboxylic acids and 2-isocyanobiaryls has been developed. Without the need of any external photosensitizer, oxidant, and reductant, this method offers a mild and green approach for the synthesis of diverse alcohols in moderate to good yields. A mechanism indicated that an electron donor-acceptor complex-driven decarboxylation, radical addition/cyclization, and in situ photochemical reduction of ketones to alcohols could be involved in the reaction.
Diazotrifluoroethyl Radical: A CF3-Containing Building Block in [3 + 2] Cycloaddition
Zhao, Wen-Wen,Shao, Yong-Chao,Wang, An-Ni,Huang, Jia-Li,He, Chun-Yang,Cui, Bao-Dong,Wan, Nan-Wei,Chen, Yong-Zheng,Han, Wen-Yong
supporting information, p. 9256 - 9261 (2021/12/06)
We present herein a visible-light-induced [3 + 2] cycloaddition of a hypervalent iodine(III) reagent with α-ketoacids for the construction of 5-CF3-1,3,4-oxadiazoles that are of importance in medicinal chemistry. The reaction proceeds smoothly without a photocatalyst, metal, or additive under mild conditions. Different from the well-established trifluorodiazoethane (CF3CHN2), the diazotrifluoroethyl radical [CF3C(·)N2], a trifluoroethylcarbyne (CF3C?:) equivalent and an unusual CF3-containing building block, is involved in the present reaction system.
