16241-31-9Relevant academic research and scientific papers
Tropolones as lead-like natural products: The development of potent and selective histone deacetylase inhibitors
Ononye, Sophia N.,Vanheyst, Michael D.,Oblak, E. Zachary,Zhou, Wangda,Ammar, Mohamed,Anderson, Amy C.,Wright, Dennis L.
supporting information, p. 757 - 761 (2013/09/02)
Natural products have long been recognized as a rich source of potent therapeutics but further development is often limited by high structural complexity and high molecular weight. In contrast, at the core of the thujaplicins is a lead-like tropolone scaf
The furan route to tropolones: Probing the antiproliferative effects of β-thujaplicin analogs
Zachary Oblak,Bolstad, Erin S. D.,Ononye, Sophia N.,Priestley, Nigel D.,Kyle Hadden,Wright, Dennis L.
, p. 8597 - 8604 (2013/01/15)
A direct route to analogs of the naturally occurring tropolone β-thujaplicin has been developed in just four steps from furan. Using this method, a series of derivatives were synthesized and evaluated. Several of these compounds demonstrated very high levels of potency against bacterial and fungal pathogens with good selectivity over mammalian cells.
