162425-06-1

Upstream product

• 142635-87-8 (E)-2-cyanocinnamate of (R)-pantolactone 
• 162272-49-3 (R)-Pantolactone (1R,6S)-1-cyano-6-phenyl-3-cyclohexene-1-carboxylate 

Downstream Products

• 162425-07-2 (1R,2S)-1-Cyano-2-phenyl-1-cyclohexanecarboxylic acid 
• 165882-91-7 (1R,6S)-methyl 1-cyano-6-phenyl-3-cyclohexene-1-carboxylate 
• 190074-04-5 (1R,6S)-1-Carbamoyl-6-phenyl-cyclohex-3-enecarboxylic acid methyl ester 
• 190074-08-9 (1R,2S,5S)-1-Carbamoyl-5-hydroxy-2-phenyl-cyclohexanecarboxylic acid methyl ester 
• 190074-06-7 (1R,2S,4R,5R)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester 
• 165882-92-8 Methyl (1R,2S)-1-cyano-2-phenyl-1-cyclohexanecarboxylate 
• 165882-94-0 (1R,2S)-1-hydroxymethyl-2-phenyl-1-cyclohexanecarbonitrile 
• 165882-93-9 (1R,2S)-methyl 1-aminomethyl-2-phenyl-1-cyclohexanecarboxylate 
• 1026636-61-2 (1R,2S)-1-Cyano-2-phenyl-1-cyclohexanecarboxylic acid chloride 
• 162425-16-3 Methyl (1R,2S)-1-(aminocarbonyl)-2-phenyl-1-cyclohexanecarboxylate 
• 162425-17-4 Methyl (1S,2S)-1-isocyanato-2-phenyl-1-cyclohexanecarboxylate 
• 1025813-85-7 (1R,2S)-1-Cyano-2-phenyl-cyclohexanecarbonyl azide 

Relevant academic research and scientific papers

Synthesis of a new type of conformationally constrained α,α-disubstituted-β-amino acids and β-lactams in enantiomerically pure form

Optically active cis-, 8a and 8b, and trans-1-aminomethyl-2-phenylcyclohexane-1-carboxylic acids, 9a and 9b, were obtained starting from 1,3-butadiene using Diels-Alder cycloadditions with chiral (E)-2-cyanocinnamates as key steps and following a protocol

Asymmetric Diels-Alder Reactions of Chiral (E)-2-Cyanocinnamates. 2. Synthesis of the Four 1-Amino-2-phenyl-1-cyclohexanecarboxylic Acids in Enantiomerically Pure Form

High and complementary diastereoselectivities were obtained in the asymmetric Diels-Alder reactions of chiral (E)-2-cyanocinnamates with butadiene when (S)-ethyl lactate and (R)-pantolactone were used as chiral auxiliaries in the presence of TiCl4.The mos