162504-75-8

Basic information

• Product Name: METHYL N-BOC-4-PIPERIDINEPROPIONATE
• Synonyms: N-BOC-4-PIPERIDINYLPROPIONIC ACID METHYL ESTER;METHYL N-BOC-4-PIPERIDINEPROPIONATE;1-Boc-4-Piperidinylpropionic Acid Methyl Ester;tert-butyl 4-(3-Methoxy-3-oxopropyl)piperidine-1-carboxylate;1-Boc-4-piperidinepropanoic acid methyl ester
• CAS NO: 162504-75-8
• Molecular Formula: C₁₄H₂₅NO₄
• Molecular Weight: 271.35
• Product Categories: pharmacetical
• Mol File: 162504-75-8.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 339.2 °C at 760 mmHg
• Flash Point: 158.9 °C
• Appearance: /
• Density: 1.048 g/cm³
• Vapor Pressure: 9.35E-05mmHg at 25°C
• Refractive Index: 1.467
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -1.51±0.40(Predicted)
• CAS DataBase Reference: METHYL N-BOC-4-PIPERIDINEPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL N-BOC-4-PIPERIDINEPROPIONATE(162504-75-8)
• EPA Substance Registry System: METHYL N-BOC-4-PIPERIDINEPROPIONATE(162504-75-8)

Safety Data

• Hazardous Substances Data: 162504-75-8(Hazardous Substances Data)

Usage

Uses

1-[1,1-Dimethylethoxy)?carbonyl]?-?4-piperidinepropanoic Acid Methyl Ester is used to prepare arginylglycylaspartic acid derivatives as fibrinogen receptor antagonists.

InChI:InChI=1/C14H25NO4/c1-14(2,3)19-13(17)15-9-7-11(8-10-15)5-6-12(16)18-4/h11H,5-10H2,1-4H3

Upstream product

• 365998-55-6 (E)-tert-butyl-4-(3-methoxy-3-oxoprop-1-en-1-yl)piperidine-1-carboxylate 
• 186581-53-3 diazomethane 
• 154775-43-6 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid 
• 292638-85-8 acrylic acid methyl ester 
• 74-88-4 methyl iodide 
• 194933-85-2 4-((E)-2-Methoxycarbonyl-vinyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 498-94-2 isonipecotic acid 

Downstream Products

• 154775-43-6 3-(1-(tert-butoxycarbonyl)piperidin-4-yl)propanoic acid 
• 1085837-44-0 2,2-dimethyl-3-{5'-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-4-yl}-propionic acid 
• 156185-63-6 N-Boc-piperidin-4-yl-propanol 

Relevant articles and documents

Catalyst-Free Deaminative Functionalizations of Primary Amines by Photoinduced Single-Electron Transfer

The use of pyridinium-activated primary amines as photoactive functional groups for deaminative generation of alkyl radicals under catalyst-free conditions is described. By taking advantage of the visible light absorptivity of electron donor–acceptor complexes between Katritzky pyridinium salts and either Hantzsch ester or Et3N, photoinduced single-electron transfer could be initiated in the absence of a photocatalyst. This general reactivity platform has been applied to deaminative alkylation (Giese), allylation, vinylation, alkynylation, thioetherification, and hydrodeamination reactions. The mild conditions are amenable to a diverse range of primary and secondary alkyl pyridiniums and demonstrate broad functional group tolerance.

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Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS

Cyclopentyl compounds linked to a benzoxazinyl group through an amido moiety utilizing the ring nitrogen of the benzoxazine, and further substituted with a heterocyclic moiety, such compounds represented by formula (I): which are used to modulate the CCR-