162536-42-7

Basic information

• Product Name: (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester
• Synonyms: (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester
• CAS NO: 162536-42-7
• Molecular Weight: 280.367
• Mol File: 162536-42-7.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester(162536-42-7)
• EPA Substance Registry System: (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester(162536-42-7)

Safety Data

• Hazardous Substances Data: 162536-42-7(Hazardous Substances Data)

Upstream product

• 7535-56-0 N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester 
• 64411-37-6 N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester 
• 165727-45-7 tert-butyl ((2S,3S)-4-chloro-3-hydroxy-1-phenylbutan-2-yl)carbamate 
• 102123-74-0 (S)-tert-butyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate 
• 67729-36-6 Boc-Phe-O-COO-isoBu 
• 60398-41-6 (3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate 
• 174302-72-8 (S)-3-tert-butoxycarbonylamino-1-nitro-4-phenyl-2-butanone 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 72155-45-4 Boc-L-phenylalaninal 
• 162536-72-3 [R-(R*,S*)]-[3-Azido-2-hydroxy-1-(phenylmethyl) propyl]carbamic acid, 1,1-dimethylethyl ester 
• 161282-72-0 (2S,3R)-N-tert-butyloxycarbonyl-2-amino-3-hydroxy-1-phenyl-4-nitrobutane 
• 98760-08-8 (1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester 

Downstream Products

• 162538-40-1 (R-(R*,S*))->bis 1,1-dimethylethyl phenylmethyl ester 
• 162538-49-0 [(1S,2R)-3-((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butylamino)-1-benzyl-2-hydroxy-propyl]-carbamic acid tert-butyl ester 
• 162538-18-3 (1S-(1R*,2S*(2S,3R*)))-<3-<<3-<<(dimethylethoxy)carbonyl>amino>-2-hydroxy-4-(4-hydroxyphenyl)butyl>amino>-2-hydroxy-1-(2-phenylmethyl)propyl>carbamic acid 1,1-dimethylethyl ester 
• 165727-48-0 {(1S,2R)-3-[((2R,3S)-3-Amino-2-hydroxy-5-phenyl-pentyl)-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 162538-43-4 {(1S,2R)-3-[((2R,3S)-3-Amino-2-hydroxy-4-phenyl-butyl)-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 162536-43-8 {(1S,2R)-3-[[(2R,3S)-3-Amino-2-hydroxy-4-(4-hydroxy-phenyl)-butyl]-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 165727-49-1 ((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-5-phenyl-pentyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 162538-17-2 [(2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-(4-hydroxy-phenyl)-butyl]-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 165727-47-9 {(1S,2R)-1-Benzyl-3-[((2R,3S)-3-benzyloxycarbonylamino-2-hydroxy-5-phenyl-pentyl)-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 162541-37-9 ((2R,3S)-3-Benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyl)-((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-carbamic acid 2-trimethylsilanyl-ethyl ester 
• 162538-16-1 {(1S,2R)-1-(4-Benzyloxy-benzyl)-3-[((2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butyl)-(2-trimethylsilanyl-ethoxycarbonyl)-amino]-2-hydroxy-propyl}-carbamic acid benzyl ester 
• 162538-15-0 {(1S,2R)-1-Benzyl-3-[(2R,3S)-3-benzyloxycarbonylamino-4-(4-benzyloxy-phenyl)-2-hydroxy-butylamino]-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 162538-21-8 [(1S,2R)-3-((2R,3S)-3-tert-Butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-1-phenethyl-propyl]-carbamic acid benzyl ester 
• 161302-38-1 <(R,R)-3-<<(R,S)-3-<<(1,1-dimethylethoxy)carbonyl>amino>-2-hydroxy-4-phenylbutyl>amino>-2-hydroxy-1-(phenylmethyl)propyl>carbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

Intermediate reaches reed that Wei new synthetic process of the

The invention provides a novel synthesis process of Darunavir intermediate, N-tertbutyloxycarbonyl-L-phenylalanine is used as a raw material, esterification, condensation, reduction, hydrogenation and reduction amination, and other reactions are carried out for preparing the key intermediate of Darunavir: (2R,3S)-3-(tert-butyloxycarbonyl)amino-1-[(2-methyl propyl)amino]-4-phenyl-2-butanol. The new synthesis process of Darunavir intermediate has the advantages of mild reaction condition, simple operation, and high reaction selectivity and yield, and the process is suitable for industrial production.

BETA-SECRETASE INHIBITING COMPOUNDS

Disclosed are compounds represented by Formula (I) as defined in the specification, or pharmaceutically acceptable salts or isomers thereof, and a pharmaceutical composition for inhibiting beta-secretase activity comprising a therapeutically effective amount of the same.

INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS

The present invention relates to new indole compounds, pharmaceutically acceptable salts or isomers thereof which are useful for the prevention or treatment of cellular necrosis and necrosis-associated diseases. The present invention also relates to a method and a composition for the prevention or treatment of cellular necrosis and necrosis-associated diseases, comprising said indole compounds as an active ingredient.