64411-37-6

Basic information

• Product Name: N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester
• Synonyms: N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester
• CAS NO: 64411-37-6
• Molecular Weight: 341.407
• Mol File: 64411-37-6.mol

Chemical Properties

• CAS DataBase Reference: N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester(64411-37-6)
• EPA Substance Registry System: N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenyl ester(64411-37-6)

Safety Data

• Hazardous Substances Data: 64411-37-6(Hazardous Substances Data)

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 108-95-2 phenol 

Downstream Products

• 161282-72-0 (2S,3R)-N-tert-butyloxycarbonyl-2-amino-3-hydroxy-1-phenyl-4-nitrobutane 
• 162536-42-7 (1S,2R)-(3-amino-1-benzyl-2-hydroxy-propyl)-carbamic acid tert butyl ester 
• 160232-08-6 (2R,3S)-3-tert-butoxycarbonylamino-1-isobutylamino-4-phenyl-2-butanol 
• 72155-45-4 Boc-L-phenylalaninal 

Relevant articles and documents

Intermediate reaches reed that Wei new synthetic process of the

The invention provides a novel synthesis process of Darunavir intermediate, N-tertbutyloxycarbonyl-L-phenylalanine is used as a raw material, esterification, condensation, reduction, hydrogenation and reduction amination, and other reactions are carried out for preparing the key intermediate of Darunavir: (2R,3S)-3-(tert-butyloxycarbonyl)amino-1-[(2-methyl propyl)amino]-4-phenyl-2-butanol. The new synthesis process of Darunavir intermediate has the advantages of mild reaction condition, simple operation, and high reaction selectivity and yield, and the process is suitable for industrial production.

Selective esterifications of primary alcohols in a water-containing solvent

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.

Selective esterifications of primary alcohols in a water-containing solvent

Oxyma and an oxyma derivative, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 2-cyano-2-(hydroxyimino)acetate (5b), displayed a remarkable effect on selective esterifications of primary alcohols. A wide range of carboxylic acids could be esterified with primary alcohols by using EDCI, NaHCO3, and Oxyma or Oxyma derivative 5b in 5% H2O-CH3CN. Oxyma derivative 5b is particularly useful, since it could be removed after the reaction via a simple basic or an acidic aqueous workup procedure.

Preparation of boc-amino-acid or peptide aldehydes via reduction of corresponding phenyl esters

A new alternative method for the preparation of amino-acid and peptide aldehydes based on reduction of corresponding phenyl esters with lithium tri(tert-butoxy)aluminium hydride is described.