152438-62-5Relevant articles and documents
Synthesis and pharmacokinetic profile of highly deuterated brecanavir analogs
Velthuisen, Emile J.,Baughman, Todd M.,Johns, Brian A.,Temelkoff, David P.,Weatherhead, Jason G.
, p. 202 - 212 (2013/07/27)
Several highly deuterated analogs of the HIV-1 protease inhibitor brecanavir have been prepared to study the effect of deuterium upon metabolic stability. The sites for deuterium incorporation were initially chosen to maximize the potential for a kinetic isotope effect; locations where C-H bond breaking is the rate limiting step. The analogs have been profiled in both in vitro and in vivo pharmacokinetic studies and the result will be described herein.
PROCESS FOR PRODUCING AMINOEPOXIDE
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Page 9, (2010/02/10)
The present invention relates to a method of producing N-carbamate protected-3-amino-1,2-epoxy-4-(hydroxy substituted phenyl)butane at a high optical purity in a high yield, by hydrogenating N-carbamate protected-3-amino-1-chloro-2-hydroxy-4-(benzyloxy su
A practical method for the preparation of α'-chloroketones of N-carbanaate protected-α-aminoacids
Chen, Ping,Cheng, Peter T. W.,Spergel, Steven H.,Zahler, Robert,Wang, Xuebao,Thottathil, John,Barrish, Joel C.,Polniaszek, Richard P.
, p. 3175 - 3178 (2007/10/03)
A practical method for the preparation of α-N-BOC-epoxides from protected amino acid esters based on the Kowalski homologation reaction is described. This procedure can be readily performed on a large scale without the use of hazardous reagents and has allowed preparation of epoxides 3 in multi-kilogram quantities.