162599-94-2Relevant academic research and scientific papers
Optical resolution of aminoisobobutyric acid
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Page column 9, (2008/06/13)
A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.
Total synthesis of cryptophycins. Revision of the structures of cryptophycins A and C
Barrow, Russell A.,Hemscheidt, Thomas,Liang, Jian,Paik, Seunguk,Moore, Richard E.,Tius, Marcus A.
, p. 2479 - 2490 (2007/10/02)
The convergent total synthesis of cryptophycins C and D is described. It has been shown that in both natural products the absolute configuration of the α-amino acid corresponds to the D-series. The structural assignment for cryptophycin C has been correct
