162599-95-3

Upstream product

• 162599-94-2 (R)-2-[(2E,7E)-(5S,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-8-phenyl-octa-2,7-dienoylamino]-3-(3-chloro-4-methoxy-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester 

Downstream Products

• 186193-23-7 (S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 195818-25-8 (S)-2-(3-tert-Butoxycarbonylamino-2,2-dimethyl-propoxy)-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 204376-51-2 (S)-2-{[1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarbonyl]-amino}-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 204376-52-3 (S)-2-[(1-Aminomethyl-cyclopropanecarbonyl)-amino]-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-1-carboxy-2-(3-chloro-4-methoxy-phenyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 204376-54-5 (E)-(6S,9S,15R)-15-(3-Chloro-4-methoxy-benzyl)-6-isobutyl-9-((E)-(R)-1-methyl-3-phenyl-allyl)-8-oxa-5,14,17-triaza-spiro[2.15]octadec-11-ene-4,7,13,16-tetraone 
• 204376-49-8 (S)-2-Amino-4-methyl-pentanoic acid (E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyl ester 
• 186256-68-8 cryptophycin 53 
• 186256-67-7 cryptophycin 52 
• 457884-58-1 1-(tert-Butoxycarbonylamino-methyl)-cyclopropanecarboxylic acid (S)-1-((E)-(1S,2R)-1-{(E)-3-[(R)-2-(3-chloro-4-methoxy-phenyl)-1-(2,2,2-trichloro-ethoxycarbonyl)-ethylcarbamoyl]-allyl}-2-methyl-4-phenyl-but-3-enyloxycarbonyl)-3-methyl-butyl ester 

Relevant academic research and scientific papers

Total synthesis of cryptophycins. Revision of the structures of cryptophycins A and C

The convergent total synthesis of cryptophycins C and D is described. It has been shown that in both natural products the absolute configuration of the α-amino acid corresponds to the D-series. The structural assignment for cryptophycin C has been correct

Optical resolution of aminoisobobutyric acid

A process for resolving amino protected racemic 3-amino-2-methylpropionic acid which comprises the steps of: (1) reacting said amino protected acid with a protected amino group with an enantiomer of a chiral amine to form diastereomeric salts; (2) recrystallizing the diastereomeric salts from ethyl acetate to separate the diastereomeric salts into crystal fractions; and (3) releasing the resolved acid from the diastereomeric salt by treating the diastereomeric salt with a basic solution is disclosed. A process for the preparation of the cryptophycin molecules is also disclosed.