1626-42-2

Usage

Derived from

1,3-dimethylbenzene (m-xylene)

Functional group

Chloropropoxy

Usage

Intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds; solvent; chemical research

Potential hazard

Irritant

Handling precautions

Handle with care and use in a controlled environment

Importance

Significant chemical in organic chemistry and industrial research

Upstream product

• 857231-77-7 3-(2,6-dimethyl-phenoxy)-propan-1-ol 
• 576-26-1 2.6-dimethylphenol 
• 109-70-6 1.3-chlorobromopropane 

Downstream Products

• 1626-40-0 4-(2,6-dimethyl-phenoxy)-butane-nitrile 
• 1614-23-9 4-(2,6-Dimethyl-phenyoxy)-butylamin 
• 67227-05-8 N-[4-(2,6-Dimethyl-phenoxy)-butyl]-guanidin 
• 119917-34-9 2-[(N-(3-(2,6-Dimethyl-phenoxy)-propyl)-piperidin-3-yl)-methyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride 

Relevant academic research and scientific papers

3-PHENYL-N- ((1, 3, 4) THIADIAZOL-2-YL) -ACRYLAMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF ESTROGEN-RELATED RECEPTORS FOR THE TREATMENT OF E.G. CANCER, RHEUMATOID ARTHRITIS OR NEUROLOGICAL DISORDERS

Compounds of formula (I) are provided as well as compositions and methods of using compounds of formula (I) for modulating the activity of the estrogen-related receptors and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder related to the activity of the estrogen-related receptor. Considering the wide range of activity of the nuclear hormone receptor ERRα, the compounds described herein which are capable of modulating ERRα activity, are useful for treating a range of disease states including cancer, diabetes, obesity, hyperlipidermia, arthritis, atherosclerosis, osteoporosis, anxiety, depression, Parkinson’s disease and Alzheimer’s disease. Formula (I). The substituents are defined in the claims.

Selectivity in alkylation of phenols with 1-bromo-3-chloropropane using phase-transfer catalysis

The use of various phase-transfer catalysts in the alkylation of phenol and substituted phenols with 1-bromo-3-chloropropane was investigated. When a quarternary ammonium salt of the general formula R'4N+ X-, where R' = alkyl with a minimum chain length of 4 was used, a mixture of 1-aryloxy-3-chloropropane and 1-aryloxy-3-bromopropane resulted. The effect of counterion, added potassium bromide, and catalysts other than quarternary ammonium salts were assessed for the halopropylation of 2,5-dimethylphenol.