16263-54-0

Basic information

• Product Name: 3,6-DICHLORO-1,2-BENZISOXAZOLE
• Synonyms: 3,6-DICHLORO-1,2-BENZISOXAZOLE;3,6-Dichlorobenzo[d]isoxazole
• CAS NO: 16263-54-0
• Molecular Formula: C7H3Cl2NO
• Molecular Weight: 188.01
• Mol File: 16263-54-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 290.1±20.0 °C(Predicted)
• Appearance: /
• Density: 1.522±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -6.76±0.30(Predicted)
• CAS DataBase Reference: 3,6-DICHLORO-1,2-BENZISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DICHLORO-1,2-BENZISOXAZOLE(16263-54-0)
• EPA Substance Registry System: 3,6-DICHLORO-1,2-BENZISOXAZOLE(16263-54-0)

Safety Data

• Hazardous Substances Data: 16263-54-0(Hazardous Substances Data)

Usage

General Description

3,6-Dichloro-1,2-Benzisoxazole is a chemical compound that belongs to the class of organic compounds known as benzisoxazoles. Like other benzisoxazoles, it is characterized by a benzene ring fused to an isoxazole ring. However, the presence of two chlorine atoms at the third and sixth positions of the benzisoxazole ring distinguishes this compound. The properties of this compound highly depend on its isomer type. Due to its potential bioactive properties and utility in synthesis and chemical reactions, this chemical is extensively utilized in various fields such as medicine, pharmacology, agriculture, and chemical research. However, it isn't widespread and may be harmful if improperly managed or processed.

Upstream product

• 5106-98-9 4-chlorosalicylic acid 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 
• 61799-78-8 4-chloro-N,2-dihydroxybenzamide 
• 61977-29-5 CBIO 
• 61977-29-5 6-chloro-benzo[d]isoxazol-3-ol 

Downstream Products

• 1351534-32-1 (2R)-2-[4-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-benzimidazol-1-yl]methyl]phenoxy]propanoic acid 
• 1351534-31-0 (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-benzimidazol-1-yl]methyl]phenoxy]propanoic acid 
• 668489-65-4 3-[1-(6-chloro-benzo[d]isoxazol-3-yl)-2-methyl-5-trifluoromethoxy-1H-indol-3-yloxy]-phenol 

Relevant articles and documents

Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia

PROBLEM TO BE SOLVED: To provide an agent for treating schizophrenia and related neuropsychiatric diseases.SOLUTION: This invention provides an aralkylpiperidine (or piperazine) derivative represented by formula (1), where A ring is a 5-7 membered heterocycle including N, with the heterocycle including a hetero atom arbitrarily selected from O, S, N; X is O, an amino group or a substituted amino group; Z is CH, N or C; Y is O, N or S; n is an integer of 1-5; and R1-R6 are H, a C1-C4 alkyl group or the like.

Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents

Members of the series of title compounds were tested for potential antipsychotic activity in relevant receptor binding assays and behavioral screens.Structure-activity relationships within the series are discussed.Compound 24 (BMY 13859-1), a (1,2-benzisothiazol-3-yl)piperazine derivative, was selected for further study because of its potent and selective profile in primary CNS tests.It was active in the Sidman avoidance paradigm and blocked amphetamine-induced stereotyped behavior in dogs for up to 7 h.The compound's lack of typical neuroleptic-like effects in therat catalepsy test and its failure to produce dopamine receptor supersensitivity following chronic administration indicate that it should not cause the movement disorders commonly associated with antipsychotic therapy.Although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile.Compound 24 is currently undergoing clinical evaluation in schizophrenic patients.