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Usage

Uses

Used in Organic Synthesis:
4-CHLORO-N,2-DIHYDROXYBENZAMIDE is used as an intermediate in the synthesis of various organic compounds. Its unique structure and reactivity make it a valuable building block for the development of new molecules with specific properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-CHLORO-N,2-DIHYDROXYBENZAMIDE is used as a starting material for the development of new drugs. Its chemical properties allow for the creation of novel drug candidates with potential therapeutic effects. Researchers can modify its structure to explore its potential as a treatment for various diseases and conditions.
Used in Chemical Research:
4-CHLORO-N,2-DIHYDROXYBENZAMIDE is also utilized in chemical research to study its properties and reactivity. Understanding its behavior in different chemical reactions can provide insights into the development of new synthetic methods and the discovery of new compounds with unique characteristics.
Used in Material Science:
In the field of material science, 4-CHLORO-N,2-DIHYDROXYBENZAMIDE can be used to develop new materials with specific properties. Its incorporation into polymers or other materials can result in materials with improved characteristics, such as enhanced stability, reactivity, or selectivity.
Overall, 4-CHLORO-N,2-DIHYDROXYBENZAMIDE is a versatile chemical compound with a wide range of potential applications in various fields, including organic synthesis, pharmaceutical research, chemical research, and material science. Its unique structure and properties make it a valuable tool for scientists and researchers in these industries.

InChI:InChI=1/C7H6ClNO3/c8-4-1-2-5(6(10)3-4)7(11)9-12/h1-3,10,12H,(H,9,11)

Upstream product

• 1800-54-0 phenyl 4-fluoro-2-hydroxybenzoate 
• 22717-55-1 methyl 4-chloro-2-hydroxybenzoate 

Downstream Products

• 61977-29-5 6-chloro-benzo[d]isoxazol-3-ol 
• 16263-54-0 3,6-dichlorobenzisoxazole 
• 61977-29-5 CBIO 
• 63482-58-6 7-chloro-2-(2-chloro-ethyl)-3-hydroxy-2,3-dihydro-benzo[e][1,3]oxazin-4-one 

Relevant academic research and scientific papers

Chromatography-free, Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids to 3-hydroxybenzisoxazoles

The Mitsunobu reaction has become one of the most powerful tools to alkylate acidic pronucleophiles. A significant caveat of Mitsunobu chemistry, however, is that the reaction mixture is often plagued with purification problems owing to the phosphine oxide and hydrazine dicarboxylate by-products. In addition to the development of more readily separable Mitsunobu reagents, the product's physicochemical properties may be exploited to facilitate purification. In this regard, we present a swift and efficient preparation of 3-hydroxybenzisoxazoles by the Mitsunobu-triggered heterocyclizations of salicylhydroxamic acids, which can be isolated by an acid–base work-up. As expected, a range of functional groups was compatible with the chemistry.

Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia

PROBLEM TO BE SOLVED: To provide an agent for treating schizophrenia and related neuropsychiatric diseases.SOLUTION: This invention provides an aralkylpiperidine (or piperazine) derivative represented by formula (1), where A ring is a 5-7 membered heterocycle including N, with the heterocycle including a hetero atom arbitrarily selected from O, S, N; X is O, an amino group or a substituted amino group; Z is CH, N or C; Y is O, N or S; n is an integer of 1-5; and R1-R6 are H, a C1-C4 alkyl group or the like.

ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA

The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.

Substituted benzisoxazole and benzisothiazole herbicidal agents

There are provided substituted benzisoxazole and benzisothiazole compounds having the structural formula I STR1 Further provided are compositions and methods comprising those compounds for the control of undesirable plant species.

Synthesis and Biological Evaluation of 1-(1,2-Benzisothiazol-3-yl)- and (1,2-Benzisoxazol-3-yl)piperazine Derivatives as Potential Antipsychotic Agents

Members of the series of title compounds were tested for potential antipsychotic activity in relevant receptor binding assays and behavioral screens.Structure-activity relationships within the series are discussed.Compound 24 (BMY 13859-1), a (1,2-benzisothiazol-3-yl)piperazine derivative, was selected for further study because of its potent and selective profile in primary CNS tests.It was active in the Sidman avoidance paradigm and blocked amphetamine-induced stereotyped behavior in dogs for up to 7 h.The compound's lack of typical neuroleptic-like effects in therat catalepsy test and its failure to produce dopamine receptor supersensitivity following chronic administration indicate that it should not cause the movement disorders commonly associated with antipsychotic therapy.Although 24 has potent affinity for dopaminergic binding sites, its even greater affinity for serotonin receptors suggests that a serotonergic component may be relevant to its atypical profile.Compound 24 is currently undergoing clinical evaluation in schizophrenic patients.