162660-05-1

Basic information

• Product Name: ((S)-1-{2-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester
• Synonyms: ((S)-1-{2-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester
• CAS NO: 162660-05-1
• Molecular Weight: 546.707
• Mol File: 162660-05-1.mol

Chemical Properties

• CAS DataBase Reference: ((S)-1-{2-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-{2-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester(162660-05-1)
• EPA Substance Registry System: ((S)-1-{2-[(S)-2-((S)-1-Hydroxymethyl-3-methyl-butylcarbamoyl)-pyrrolidin-1-yl]-1,1-dimethyl-2-oxo-ethylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester(162660-05-1)

Safety Data

• Hazardous Substances Data: 162660-05-1(Hazardous Substances Data)

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 128422-17-3 Z-Leu-Aib-Pro-OH 
• 147-85-3 L-proline 
• 177747-22-7 methyl N-(2,2-dimethyl-2H-azirin-3-yl)-L-prolinate 
• 177747-24-9 (S)-1-(2-Methyl-thiopropionyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 177747-23-8 (S)-methyl 1-(isobutyryl)pyrrolidine-2-carboxylate 
• 84758-76-9 Z-L-Leu-Aib-L-Pro-OMe 
• 2018-66-8 Z-Leu-OH 

Downstream Products

• 177747-31-8 Z-Ser(t-Bu)-Val-Aib-Pro-Aib-Leu-Aib-Pro-Leuol 

Relevant articles and documents

A new 3-amino-2H-azirine as an Aib-Pro synthon: Synthesis of the C-terminal nonapeptide of trichovirin I 1B

The synthesis of methyl N-(2,2-dimethyl-2H-azirin-3-yl)-L-prolinate (3), a novel 3-amino-2H-azirine, is described. It is shown that the reaction of COCl2 with thioamide 5 is remarkably faster than with the corresponding amide 4, and the yield of 3 is much better in the synthesis starting with 5. The 3-amino-2H-azirine 3 has been used as a building block of the dipeptide moieties Aib-Pro in the synthesis of nonapeptide 17, the C-terminal 6-14 segment of the peptaibole trichovirin I 1B. The structure of 17 was established by single-crystal X-ray crystallography.