162706-00-5Relevant academic research and scientific papers
Process for the preparation of iopamidol and 5-amino-2,2-dialkyl-1,3-dioxanes
-
, (2008/06/13)
A process for the preparation of Iopamidol and 5-amino-2,2-dialkyl-1,3-dioxanes of formula STR1 wherein R and R1 are the same or different and represent a straight or branched C1 and C2 alkyl group or together with the carbon atom to which they are bonded, form a C5 -C6 cycloaliphatic ring; comprising the transformation of a 2,2-dialkyl-1,3-dioxane-5-carboxylic acid ester of formula STR2 wherein R2 represents a straight or branched C1 -C2 alkyl group, a phenyl optionally substituted by nitro groups or a benzyl; by treatment with ammonia into the corresponding amides and the subsequent rearrangement of the latter into the compounds of formula I, by treatment with a hypohalogenite. The resultant ketals may be used as is, or be converted to 2-amino-1,3-propanediol, and reacted with 5-amino-2,4,6-triiodo-isophthalic acid dichloride or, alternatively,L-5-(2-acetoxy-propionylamino)-2,4,6-triido-isophthalic acid dichloride, to produce Iopamidol.
Proces for the preparation of 5-amino-2,2-dialkyl-1,3-dioxanes
-
, (2008/06/13)
A process for the preparation of 5-amino-2,2-dialkyl-1,3-dioxanes of formula wherein R and R1 have the meanings reported in the description, comprising the transformation of a 2,2-dialkyl-1,3-dioxan-5-carboxylic acid ester of formula wherein R2 has the meanings reported in the description into the corresponding amide and the subsequent rearrangement of this latter into the compounds of formula I, is described.
