82962-54-7

Usage

Uses

Used in Pharmaceutical Synthesis:
2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane is utilized as an intermediate in the synthesis of pharmaceuticals, playing a crucial role in the development of various medicinal compounds. Its unique structure allows for versatile chemical reactions, facilitating the creation of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane serves as an intermediate for the synthesis of various agrochemicals, including pesticides and herbicides. Its involvement in these processes helps to develop more effective and targeted agricultural products, contributing to enhanced crop protection and yield.
Used as a Solvent in Organic Reactions:
2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane is employed as a solvent for a range of organic reactions due to its low volatility and relative stability under normal conditions. Its ability to dissolve a variety of organic compounds makes it a valuable asset in controlled chemical environments, facilitating smoother reaction processes and improved product yields.
Used as a Reagent in Chemical Synthesis:
In addition to its role as an intermediate and solvent, 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane is also used as a reagent in chemical synthesis. Its participation in various chemical reactions contributes to the formation of desired products, further expanding its utility in the field of chemistry.
It is important to handle 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane with care and adhere to proper safety protocols to minimize any potential hazards associated with its use.

Upstream product

• 51335-75-2 2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester 
• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 77-76-9 2,2-dimethoxy-propane 

Downstream Products

• 111935-01-4 octanoic acid, (+/-)-5,5-difluoro-4-oxo-2-<<oxy>methyl>undecyl ester 
• 111935-10-5 octadecanoic acid, 5,5-difluoro-4-oxo-2-<<oxy>methyl>heneicosanyl ester 
• 162706-00-5 5-aminocarbonyl-2,2-dimethyl-1,3-dioxane 
• 1262033-06-6 C₁₆H₂₁ClO₄ 
• 1262033-07-7 C₁₆H₂₁ClO₄ 
• 1262033-08-8 C₁₇H₂₄O₅ 
• 1262033-03-3 C₁₆H₂₂O₄ 
• 1262033-04-4 C₁₆H₂₁BrO₄ 
• 1262033-05-5 C₁₆H₂₀Cl₂O₄ 

Relevant academic research and scientific papers

Rhodium-Catalyzed Cyclization of O,ω-Unsaturated Alkoxyamines: Formation of Oxygen-Containing Heterocycles

O,ω-Unsaturated N-tosyl alkoxyamines undergo unexpected RhIII-catalyzed intramolecular cyclization by oxyamination to produce oxygen-containing heterocycles. Mechanistic studies show that an aziridine intermediate seems to be responsible for the formation of the heterocycles, possibly via a RhV species.

Synthesis of Panal Terpenoid Core

Panal is a natural bicyclic cadalane-type sesquiterpenoid with an unusual combination of stereocenters. It was isolated in 1988 as an alleged biosynthetic precursor of luciferin (a light-emitting molecule) in a bioluminescent fungus Panellus stipticus. Herein we present the first approach to the synthesis of the terpenoid skeleton of panal, which includes construction of five stereocenters, one of which is easily epimerizable. The key steps in the synthetic approach presented are high-pressure Diels-Alder reaction disobeying the ‘endo rule’, Barbier reductive allylation, and cyclization of trans-decalin ring via ring-closing metathesis.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

METHODS AND COMPOSITIONS FOR THE SYNTHESIS OF MULTIMERIZING AGENTS

The invention features methods and compositions for the synthesis of multimerizing agents.

Development of a practical and scalable synthesis of (R)- and (S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride: A useful C-4 Chiral Building Block

The development of a practical and scalable synthesis of a C-4 chiral amine building block (R)-1·HCl and (S)-1·HCl is described. This important chiral intermediate (R)-1·HCl is efficiently synthesized from the commercially available, inexpensive, and simple 2-(hydroxymethyl)-1,3- propanediol (31) using lipase-catalyzed enantioselective hydrolysis as a key reaction. Development resulted in a telescoped process that was operated successfully and reproducibly in a pilot-plant-scale synthesis, and 22 kg of chiral amine (R)-1·HCl was prepared in the first scale-up synthesis. This synthetic method is also useful for preparation of the important chiral building block (S)-1·HCl, which is the enantiomer of (R)-1·HCl.

3,5-Disubstituted pyranone analogues of highly antifungally active furanones: Conversion of biological effect from antifungal to cytostatic

A series of 3-aryl-5-acyloxymethyl-5,6-dihydro-2H-pyran-2-ones, related to highly antifungally active butenolides, was synthesized via cyclization of substituted δ-hydroxy acids as the key step, and evaluated for their in vitro antifungal activity and cytostatic activity. While the extension of the furanone ring to pyranone led to a complete loss of the antifungal effect, some of the compounds displayed promising effect against several cell lines, including the resistant colorectal carcinoma cells.

Pyrazole glucokinase activators

Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.

Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines

Novel bisphosphonate alkylating agent, tetraisopropyl (2-[(mesyloxy)methyl] propane-1,3-diyl]bis(oxymethylene)bisphosphonate 19, was synthesized from diethyl 2,2-bis-(hydroxymethyl)malonate. Decarbethoxylation of the diethyl 2,2-dimethyl-1,3-dioxane-5,5-dicarboxylate was followed by chloromethylation of 2-[(benzyloxy)methyl]propane-1,3-diol and Arbuzov reaction with triisopropyl phosphite. Bisphosphonate building block 19 was used in the alkylation of various nucleobases (2-amino-6-chloropurine, adenine, 2-amino-6-(cyclopropyl) aminopurine, cytosine, uracil and 4-methoxy-5-methylpyrimidin-2(1H)-one). N 9-Substituted purines and N1-substituted pyrimidines were converted to appropriate free bisphosphonic acids. No antiviral or cytostatic activity was detected.

Synthetic studies on spiroketal natural products. IV. A stereoselective synthesis of (3S,5S,6R,9R,R(S))-3-benzyloxymethyl-9-hydroxymethyl-5-(p-tolyl)sulfin yl-1,7-dioxaspiro[5.5]undecane, a key intermediate for talaromycins

A dioxaspiro compound (4), a common intermediate for the synthesis of talaromycin A (1) and (-)-talaromycin B (2), was synthesized by two routes utilizing two kinds of asymmetric recognition of prochiral 1,3-diols controlled by sulfinyl chirality, that is, firstly by acid promoted diastereoselective C-O bond fission of the bicyclic acetal (7) to give the dihydropyran derivative (6), which has an S-hydroxymethyl group at the C3-position (7 → 6), and secondly by diastereoselective intramolecular Michael addition of the diol (5), in which the three chiral centers at C5, C6, C9 were constructed in one step (5 → 4).

SYNTHESIS OF 5,5'-DIHYDROXYLEUCINE AND 4-FLUORO-5,5'-DIHYDROXYLEUCINE, THE REDUCTION PRODUCTS OF 4-CARBOXYGLUTAMIC AND 4-CARBOXY-4-FLUOROGLUTAMIC ACIDS

Schemes for the synthesis of 5,5'-dihydroxyleucine 3 and its 4-fluoro analog 7 involving the condensation of a suitable 'aminoacid moiety' with 2,2-dimethyl-5-iodomethyl-1,3-dioxane 15D or its fluoro analog 27A were tested.The anion of the ethyl N-diphenylmethylene-glycinate 25 gave better yields of 3 than the classical anion of diethyl acetamidomalonate.This strategy could not be successfully applied to the synthesis of 7, which could be prepared by reduction of a suitably protected 4-fluoro-4-carboxyglutamate with BMS.