82962-54-7

Basic information

• Product Name: 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane
• Synonyms: 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane;ethyl 2,2-diMethyl-1,3-dioxane-5-carboxylate;2,2-Dimethyl-[1,3]dioxane-5-carboxylic acid ethyl ester;Methyl 2,2-diMethyl-1,3-dioxane-5-carboxylate
• CAS NO: 82962-54-7
• Molecular Formula: C₉H₁₆O₄
• Molecular Weight: 188.22094
• Mol File: 82962-54-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 75℃ (0.4 Torr)
• Flash Point: 85.0±23.2℃
• Appearance: /
• Density: 1.039±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane(82962-54-7)
• EPA Substance Registry System: 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane(82962-54-7)

Safety Data

• Hazardous Substances Data: 82962-54-7(Hazardous Substances Data)

Usage

General Description

2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane is a chemical compound with the molecular formula C9H16O4. It is a cyclic organic compound with a dioxane backbone and ethoxycarbonyl and methyl substituents. 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a solvent for various organic reactions and as a reagent in chemical synthesis. 2,2-diMethyl-5-ethoxycarbonyl-1,3-dioxane has a low volatility and is considered to be relatively stable under normal conditions, making it suitable for use in controlled environments. However, it is important to handle this compound with care and follow proper safety protocols to avoid any potential hazards associated with its use.

Upstream product

• 20605-01-0 diethyl bis(hydroxymethyl)malonate 
• 77-76-9 2,2-dimethoxy-propane 
• 51335-75-2 2,2-Dimethyl-1,3-dioxacyclohexane-5,5-dicarboxylic acid,diethyl ester 

Downstream Products

• 1394849-41-2 ethyl (R,S)-3-{[tert-butyl(diphenyl)silyl]oxy}-2-(hydroxymethyl)propanoate 
• 1262033-05-5 C₁₆H₂₀Cl₂O₄ 

Relevant articles and documents

Rhodium-Catalyzed Cyclization of O,ω-Unsaturated Alkoxyamines: Formation of Oxygen-Containing Heterocycles

O,ω-Unsaturated N-tosyl alkoxyamines undergo unexpected RhIII-catalyzed intramolecular cyclization by oxyamination to produce oxygen-containing heterocycles. Mechanistic studies show that an aziridine intermediate seems to be responsible for the formation of the heterocycles, possibly via a RhV species.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Development of a practical and scalable synthesis of (R)- and (S)-3-amino-2-[(benzyloxy)methyl]propan-1-ol monohydrochloride: A useful C-4 Chiral Building Block

The development of a practical and scalable synthesis of a C-4 chiral amine building block (R)-1·HCl and (S)-1·HCl is described. This important chiral intermediate (R)-1·HCl is efficiently synthesized from the commercially available, inexpensive, and simple 2-(hydroxymethyl)-1,3- propanediol (31) using lipase-catalyzed enantioselective hydrolysis as a key reaction. Development resulted in a telescoped process that was operated successfully and reproducibly in a pilot-plant-scale synthesis, and 22 kg of chiral amine (R)-1·HCl was prepared in the first scale-up synthesis. This synthetic method is also useful for preparation of the important chiral building block (S)-1·HCl, which is the enantiomer of (R)-1·HCl.