162709-84-4

Basic information

• Product Name: 3,4,5-Tridodecyloxy benzyl chloride
• Synonyms: 3,4,5-Tridodecyloxy benzyl chloride;3,4,5-Tris(dodecyloxy)benzyl chloride;(3,4,5)12G1-CH2Cl
• CAS NO: 162709-84-4
• Molecular Formula: C₄₃H₇₉ClO₃
• Molecular Weight: 679.53856
• Mol File: 162709-84-4.mol
• Article Data: 34

Chemical Properties

• Melting Point: 49-52 °C
• Boiling Point: 700.4±55.0 °C(Predicted)
• Appearance: /
• Density: 0.925±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,4,5-Tridodecyloxy benzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4,5-Tridodecyloxy benzyl chloride(162709-84-4)
• EPA Substance Registry System: 3,4,5-Tridodecyloxy benzyl chloride(162709-84-4)

Safety Data

• Hazardous Substances Data: 162709-84-4(Hazardous Substances Data)

Usage

General Description

3,4,5-Tridodecyloxy benzyl chloride is a chemical compound with the molecular formula C33H61ClO and a molecular weight of 529.34 g/mol. It is a derivative of benzyl chloride and is composed of a benzene ring with three dodecyloxy (C12H25O) substituents attached to the 3, 4, and 5 positions. This chemical is used in various industrial processes such as the synthesis of surfactants, detergents, and as a building block for the production of other organic compounds. Additionally, it can be utilized as a reagent in organic synthesis for various functional group transformations. This chemical is considered to be an irritant and harmful if swallowed, inhaled, or comes into contact with the skin, so it should be handled with caution in a controlled laboratory environment.

Upstream product

• 138433-00-8 3,4,5-tris(dodecyloxy)benzyl alcohol 
• 99-24-1 methyl galloate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 
• 143-15-7 1-dodecylbromide 
• 117241-31-3 3,4,5-tridodecyloxy benzoic acid 
• 121-79-9 Propyl gallate 
• 1228276-91-2 propyl 3,4,5-tris(n-dodecan-1-yloxy)benzoate 
• 112-29-8 1-bromo dodecane 
• 117241-30-2 ethyl 3,4,5-tri(dodecyloxy)benzoate 
• 831-61-8 Ethyl gallate 
• 123126-39-6 methyl [3,4,5-tris(n-dodecan-1-yloxy)]benzoate 

Downstream Products

• 186031-55-0 methyl 3,4,5-tris[3',4',5'-tris(n-dodecan-1-yloxy)benzyloxy]benzoate 
• 902451-81-4 1-{4-[(3-phthalimidopropyl)oxy]phenylazo}-4-[3,4,5-tris(dodecan-1-yloxy)benzyloxy]benzene 
• 916815-63-9 C₅₁H₉₀N₂O₃ 
• 1262976-47-5 C₅₃H₈₈O₈ 
• 1207684-57-8 1,4-diiodo-2,5-bis{[3,4,5-tri(dodecoxy)phenyl]methoxy}benzene 
• 1266383-05-4 ethyl 3,4-bis(dodecyloxy)-5-[3,4,5-tris(dodecyloxy)benzyloxy]benzoate 

Relevant articles and documents

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

Efficient viral or nonviral delivery of nucleic acids is the key step of genetic nanomedicine. Both viral and synthetic vectors have been successfully employed for genetic delivery with recent examples being DNA, adenoviral, and mRNA-based Covid-19 vaccines. Viral vectors can be target specific and very efficient but can also mediate severe immune response, cell toxicity, and mutations. Four-component lipid nanoparticles (LNPs) containing ionizable lipids, phospholipids, cholesterol for mechanical properties, and PEG-conjugated lipid for stability represent the current leading nonviral vectors for mRNA. However, the segregation of the neutral ionizable lipid as droplets in the core of the LNP, the "PEG dilemma", and the stability at only very low temperatures limit their efficiency. Here, we report the development of a one-component multifunctional ionizable amphiphilic Janus dendrimer (IAJD) delivery system for mRNA that exhibits high activity at a low concentration of ionizable amines organized in a sequence-defined arrangement. Six libraries containing 54 sequence-defined IAJDs were synthesized by an accelerated modular-orthogonal methodology and coassembled with mRNA into dendrimersome nanoparticles (DNPs) by a simple injection method rather than by the complex microfluidic technology often used for LNPs. Forty four (81%) showed activity in vitro and 31 (57%) in vivo. Some, exhibiting organ specificity, are stable at 5 °C and demonstrated higher transfection efficiency than positive control experiments in vitro and in vivo. Aside from practical applications, this proof of concept will help elucidate the mechanisms of packaging and release of mRNA from DNPs as a function of ionizable amine concentration, their sequence, and constitutional isomerism of IAJDs.

Controlling the Balance of Photoluminescence and Photothermal Effect in Cyanostilbene-Based Luminescent Liquid Crystals

Molecular motions of the luminescent liquid crystals (LLCs) show a significant effect on fluorescent emission and heat generation. In this article, a series of cyanostilbene-based LLCs (CSs: CS1-6, CS1-12, CS2-6 and CS2-12) are synthesized to investigate

Anhydrous proton conduction in self-assembled and disassembled ionic molecules

In polymer based ionic conductors, the conductivity is suppressed by a low degree of chain mobility, therefore it is imperative to design a molecular system in which ionic groups can be mobilized and immobilized as a function of temperature to allow ions