16272-83-6

Upstream product

• 16272-82-5 1-Phenyl-1,4-hexadiyn-3-ol 
• 6224-91-5 trimethyl(prop-1-ynyl)silane 
• 7299-58-3 phenylpropiolyl chloride 
• 2579-22-8 Phenylpropargyl aldehyde 
• 637-44-5 phenylpropyolic acid 

Downstream Products

• 162467-59-6 2-Phenyl-6-methyl-4H-thiopyran-4-one 
• 605668-55-1 (3-dibromomethylenehexa-1,4-diynyl)benzene 
• 4300-27-0 1-phenyl-hepta-1,3,5-triyne 
• 162467-63-2 2-Phenyl-6-methyl-4H-thiopyran-4-one 1,1-dioxide 

Relevant academic research and scientific papers

Synthesis of naturally occurring acetylenes via an alkylidene carbenoid rearrangement

Naturally occurring mosquito larvicidal acetylenes 1 and 2, and analogues 3 and 4, each containing either a 1,3-butadiynyl or a 1,3,5-hexatriynyl moiety, are synthesized via a Fritsch - Buttenberg - Wiechell rearrangement. The alkylidene carbenoid interme

Syntheses of 4H-thiopyran-4-one 1,1-dioxides as precursors to sulfone-containing analogues of tetracyanoquinodimethane

Synthetic routes to the unsubstituted 4H-thiopynan-4-one 1,1-dioxide (5a), 2,6-dialkyl-substituted, 2-aryl- or 2-heteroaryl-6-alkyl-substituted, 2,6-diaryl- or diheteroaryl-substituted, and 2-heteroaryl-6-aryl-substituted 4H-thiopyran-4-one 1,1-dioxides 5b-s are described. Sodium hydrosulfide hydrate in buffered aqueous alcohol can be used as a substitute for hydrogen sulfide gas for the introduction of sulfur to methyl acrylate, to 1,5-disubstituted-1,4-pentadien-3-ones 13, or to 1,5-disubstituted-1,4-pentadiyn-3-ones 17. The double dehydrogenation of 2,3,5,6-tetrahydrothiopyran-4-one 1,1-dioxides 13 with iodine-DMSO-sulfuric acid gives thiopyran-4-one 1,1-dioxides 5 in good yield and small amounts of 1,4-pentadien-3-ones 13. 2,3,5,6-Tetrahydrothiopyran-4-one 1,1-dioxide (9) and 5,6-dihydrothiopyran-4-one 1,1-dioxide (12), which lack aryl or heteroaryl substituents, give poor yields of 4H-thiopyran-4-one 1,1-dioxide (5a) with iodine-DMSO-sulfuric acid.