1627523-17-4

Basic information

• Product Name: 1-(4-((6-nitroquinoxalin-2-yl)amino)phenyl)-3-phenylurea
• Synonyms: 1-(4-((6-nitroquinoxalin-2-yl)amino)phenyl)-3-phenylurea
• CAS NO: 1627523-17-4
• Molecular Weight: 400.396
• Mol File: 1627523-17-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-((6-nitroquinoxalin-2-yl)amino)phenyl)-3-phenylurea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-((6-nitroquinoxalin-2-yl)amino)phenyl)-3-phenylurea(1627523-17-4)
• EPA Substance Registry System: 1-(4-((6-nitroquinoxalin-2-yl)amino)phenyl)-3-phenylurea(1627523-17-4)

Safety Data

• Hazardous Substances Data: 1627523-17-4(Hazardous Substances Data)

Upstream product

• 103-71-9 phenyl isocyanate 
• 1932-32-7 N-(4-nitrophenyl)-N'-phenylurea 
• 100-01-6 4-nitro-aniline 
• 6272-25-9 2-Chloro-6-nitroquinoxaline 
• 10141-46-5 1–(4-aminophenyl)-3-phenylurea 
• 25652-34-0 6-nitroquinoxalin-2(1H)-one 
• 1196-57-2 quinoxalin-2⁽¹⁾-one 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold

In an effort to develop ATP-competitive VEGFR-2 selective inhibitors, a series of new quinoxaline-based derivatives was designed and synthesized. The target compounds were biologically evaluated for their inhibitory activity against VEGFR-2. The design of the target compounds was accomplished after a profound study of the structure activity relationship (SAR) of type-II VEGFR-2 inhibitors. Among the synthesized compounds, 1-(2-((4-methoxyphenyl)amino)-3- oxo-3,4 dihydroquinoxalin-6-yl)-3-phenylurea (VIIa) displayed the highest inhibitory activity against VEGFR-2. Molecular modeling study involving molecular docking and field alignment was implemented to interpret the variable inhibitory activity of the newly synthesized compounds.