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10141-46-5

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10141-46-5 Usage

General Description

N-(4-aminophenyl)-N''-phenylurea, also known as aminophenyl phenyl urea, is a chemical compound with the molecular formula C13H12N2O. It is a white to off-white crystalline powder that is commonly used as an intermediate in the synthesis of pharmaceuticals and pesticides. N-(4-AMINOPHENYL)-N''-PHENYLUREA has a wide range of applications in various industries, including medicine, agriculture, and chemical manufacturing. It is also used as a raw material for the production of dyes, pigments, and other organic compounds. N-(4-aminophenyl)-N''-phenylurea is considered to be relatively stable under normal conditions, but it may react with incompatible chemicals and pose hazards if not handled properly. Therefore, it is important to follow safety precautions when working with this chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 10141-46-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,1,4 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 10141-46:
(7*1)+(6*0)+(5*1)+(4*4)+(3*1)+(2*4)+(1*6)=45
45 % 10 = 5
So 10141-46-5 is a valid CAS Registry Number.

10141-46-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(4-aminophenyl)-3-phenylurea

1.2 Other means of identification

Product number -
Other names N-(4-aminophenyl)-N'-phenylurea

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10141-46-5 SDS

10141-46-5Relevant articles and documents

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking

Eldehna, Wagdy M.,Fares, Mohamed,Ibrahim, Hany S.,Aly, Mohamed H.,Zada, Suher,Ali, Mamdouh M.,Abou-Seri, Sahar M.,Abdel-Aziz, Hatem A.,Abou El Ella, Dalal A.

, p. 89 - 97 (2015)

In our effort to develop potent and effective agents with anti-proliferative activity towards HepG2 hepatocellular carcinoma cells with potential inhibitory activity against VEGFR-2, a novel series of 1-(4-((2-oxoindolin-3-ylidene)amino)phenyl)-3-arylurea

Bis amide-aromatic-ureas - Highly effective hydro- and organogelator systems

Baker,Acton,Stevens,Hayes

, p. 8303 - 8311 (2014)

A series of hydro- and organo-supergelators have been synthesised via coupling of simple bis aromatic-ureas via alkyl amide linkages. These bis amide-aromatic-ureas exhibited reduced critical gelator concentrations, improved gelator stability, mechanical

One-pot synthesis and transmembrane chloride transport properties of C3-symmetric benzoxazine urea

Roy, Arundhati,Saha, Debasis,Mukherjee, Arnab,Talukdar, Pinaki

, p. 5864 - 5867 (2016)

One-pot synthesis of a C3-symmetric benzoxazine-based tris-urea compound is discussed. 1H NMR titrations indicate a stronger Cl- binding compared that of Br- and I- by the receptor. Effective Cl- transport across liposomal membranes via a Cl-/X- antiport mechanism is confirmed. Theoretical calculation suggests that a few water molecules with N-H, C=O, and the aromatic ring of the receptor create a H-bonded polar cavity where a Cl- is recognized by O-H···Cl- interactions from five bridged water molecules.

NOVEL HYDROGELATOR

-

, (2019/08/20)

A novel hydrogelator that contains a monourea compound having a sugar structure, which can be produced by a simple method, includes a compound of the following Formula [1]: (wherein Sg is a sugar group, A is a divalent linking group, and R is a

Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents

Ghith, Amna,Youssef, Khairia M.,Ismail, Nasser S.M.,Abouzid, Khaled A.M.

, p. 111 - 128 (2018/10/24)

Different series of novel thieno [2,3-d]pyrimidine derivative (9a-d,10a-f,l,m and 15a-m) were designed, synthesized and evaluated for their ability to in vitro inhibit VEGFR-2 enzyme. Also, the cytotoxicity of the final compounds was tested against a panel of 60 different human cancer cell lines by NCI. The VEGFR-2 enzyme inhibitory results revealed that compounds 10d, 15d and 15 g are among the most active inhibitors with IC50 values of 2.5, 5.48 and 2.27 μM respectively, while compound 10a remarkably showed the highest cell growth inhibition with mean growth inhibition (GI) percent of 31.57%. It exhibited broad spectrum anti-proliferative activity against several NCI cell lines specifically on human breast cancer (T7-47D) and renal cancer (A498) cell lines of 85.5% and 77.65% inhibition respectively. To investigate the mechanistic aspects underlying the activity, further biological studies like flow cytometry cell cycle together with caspase-3 colorimetric assays were carried on compound 10a. Flow cytometric analysis on both MCV-7 and PC-3 cancer cells revealed that it induced cell-cycle arrest in the G0-G1phase and reinforced apoptosis via activation of caspase-3. Furthermore, molecular modeling studies have been carried out to gain further understanding of the binding mode in the active site of VEGFR-2 enzyme and predict pharmacokinetic properties of all the synthesized inhibitors.

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