162792-09-8

Basic information

• Product Name: 11,12-dihydro-7-triethylsilyl-10-deacetylbaccatin III
• Synonyms: 11,12-dihydro-7-triethylsilyl-10-deacetylbaccatin III
• CAS NO: 162792-09-8
• Molecular Weight: 660.877
• Mol File: 162792-09-8.mol

Chemical Properties

• CAS DataBase Reference: 11,12-dihydro-7-triethylsilyl-10-deacetylbaccatin III(CAS DataBase Reference)
• NIST Chemistry Reference: 11,12-dihydro-7-triethylsilyl-10-deacetylbaccatin III(162792-09-8)
• EPA Substance Registry System: 11,12-dihydro-7-triethylsilyl-10-deacetylbaccatin III(162792-09-8)

Safety Data

• Hazardous Substances Data: 162792-09-8(Hazardous Substances Data)

Upstream product

• 155588-21-9 7-triethylsilyl-13-dehydro-10-deacetylbaccatin III 

Downstream Products

• 175444-23-2 C₅₅H₇₃NO₁₄Si 
• 175444-20-9 C₃₃H₅₀O₉Si 

Relevant articles and documents

Baccatin III derivatives: Reduction of the C-11, C-12 double bond

Zinc-promoted reduction of 13-oxobaccatin III derivatives leads to 11,12-dihydro analogs. The reduced products are unstable and a skeleton rearrangement occurs leading to the cleavage of the C-10, C-11 bond. The 11,12-dihydrobaccatin III derivatives do not retain antitubulin activity.

Synthesis of modified baccatins via an oxidation-reduction protocol

(12R)-7-trietylsilyl-11-dihydro-10-deacetylbaccatin III (2), -deacetylbaccatin III (4) and the 7,8-seco baccatin III (5a) were synthesized from 10-deacetylbaccatin III via an oxidation-reduction protocol.