1628-19-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Chlorophenyl)-2,5-pyrrolidinedione is used as a medication for treating muscle spasms and tension due to its muscle relaxant properties. It helps in reducing the severity and frequency of muscle contractions, providing relief from discomfort and pain associated with these conditions.
1-(4-Chlorophenyl)-2,5-pyrrolidinedione is also used as an anxiolytic agent for managing anxiety. Its sedative effects help in calming the central nervous system, leading to a reduction in feelings of anxiety and stress.
Furthermore, 1-(4-CHLOROPHENYL)-2,5-PYRROLIDINEDIONE is employed as an analgesic for certain types of pain. By affecting the central nervous system, it can help in mitigating pain signals and providing relief to the patient.

Upstream product

• 541-59-3 maleiimide 
• 106-47-8 4-chloro-aniline 
• 140-53-4 p-chlorobenzyl cyanide 
• 1028257-13-7 (E)-2-(4-Chloro-phenyl)-3-methylsulfanyl-4-nitro-but-3-enenitrile 
• 398130-11-5 3-(4-chloro-phenyl)-4-methylsulfanyl-pyrrole-2,5-dione 5-oxime 
• 398130-20-6 3-(4-chlorophenyl)-4-(methylthio)-1H-pyrrole-2,5-dione 
• 58755-91-2 2-(4-chlorophenyl)succinic acid 

Downstream Products

• 21724-87-8 3-(4-chlorophenyl)-1H-pyrrole-2,5-dione 
• 120418-62-4 3-(4-chlorophenyl)pyrrolidine 
• 1239885-41-6 N-[{4-(3-chlorophenyl)-piperazin-1-yl}-methyl]-3-(4-chlorophenyl)-pyrrolidine-2,5-dione 
• 1239885-42-7 N-[{4-(3-trifluoromethylphenyl)-piperazin-1-yl}-methyl]-3-(4-chlorophenyl)-pyrrolidine-2,5-dione 
• 1239885-40-5 N-[{4-(2-chlorophenyl)-piperazin-1-yl}-methyl]-3-(4-chlorophenyl)-pyrrolidine-2,5-dione 
• 19027-44-2 N-[{4-(4-chlorophenyl)-piperazin-1-yl}-methyl]-3-(4-chlorophenyl)-pyrrolidine-2,5-dione 

Relevant academic research and scientific papers

Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones

The synthesis and anticonvulsant properties of new N-Mannich bases of 3-phenyl- (9a-d), 3-(2-chlorophenyl)- (10a-d), 3-(3-chlorophenyl)- (11a-d) and 3-(4-chlorophenyl)-pyrrolidine-2,5-diones (12a-d) were described. The key synthetic strategies involve the

Selective and tunable synthesis of 3-arylsuccinimides and 3-arylmaleimides from arenediazonium tetrafluoroborates and maleimides

A highly efficient synthetic strategy for synthesizing 3-arylsuccinimides has been developed from arenediazonium tetrafluoroborates and maleimides in the presence of TiCl3. The reactions generated 3-arylsuccinimides in satisfactory yields under mild reaction conditions. In addition, 3-arylmaleimides were obtained by the coupling of arenediazonium tetrafluoroborate and maleimides catalyzed by CuCl. This methodology provided the selective and tunable synthesis of two classes of products by simply switching different metal reagents. The methods are simple, efficient and practical.

Synthesis and anticonvulsant properties of new mannich bases derived from 3-aryl-pyrrolidine-2,5-diones. Part 1

A series of new Mannich bases of N-[(4-arylpiperazin-1-yl)-methyl]-3- (chlorophenyl)-pyrrolidine-2,5-diones 10-23 have been synthesized and evaluated for their anticonvulsant activity in maximum electroshock (MES) and subcutaneous pentylenetetrazole (scPT

Synthesis of 3-methylthio-4-aryl-3-pyrroline-2,5-diones and 3-arylpyrolidine-2,5-diones by reaction of nitroketene dithioacetal with arylacetonitriles

The reaction of nitroketene dithioacetal (1a), i.e., 2,2-bis(methylthio)-1-nitroethylene, with arylacetonitriles (2a-I) in the presence of the base like sodium hydroxide gave 4-nitrobut-2-enenitriles (3a-I) which were convened into 5-hydroxyimino-4-methylthio-3-phenyl-3-pyrrolin-2-ones (4a-i) under refluxing in methanol. Title compounds (5a-i) were readily obtained by the treatment of 4a-i with hydrochloric acid and were finally led to N-methylated products (6a-I) with methyl iodide. The reduction of maleimides (4 - 6) with zinc dust in acetic acid afforded the corresponding 3-arylpyrrolidine-2,5-diones (7a-i) that can be convened to pharmacologycally active compounds like mesembrines.