162853-45-4Relevant academic research and scientific papers
Synthesis of nucleoside 5'-deoxy-5'-difluoromethylphosphonates
Matulic-Adamic,Usman
, p. 3227 - 3230 (1994)
1-O-acetyl-2,3-di-O-benzoyl-D-ribofuranose 5-deoxy-5-difluoromethylphosphonate was synthesized in three steps from 1-O-methyl-2,3-O-isopropylidene-β-D-ribofuranose 5-deoxy-5-difluoromethylphosphonate. Condensation of this suitably derivatized sugar with silylated pyrimidines and purines afforded novel nucleoside 5'-deoxy-5'-difluoromethylphosphonates.
