1628720-66-0 Usage
Uses
Used in Pharmaceutical Industry:
Levothyroxine EP Impurity B is used as a reference compound for the development and validation of analytical methods in the pharmaceutical industry. Its presence in Thyroxine medications needs to be monitored and controlled to ensure the safety and efficacy of the final product.
Levothyroxine EP Impurity B is also used as a starting material or intermediate in the synthesis of other thyroid-related compounds, which can be further developed into new drugs or therapies for thyroid-related disorders.
Additionally, Levothyroxine EP Impurity B can be utilized in research and development to study the effects of impurities on the pharmacological properties of thyroid hormones, contributing to a better understanding of their mechanisms of action and potential side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1628720-66-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,2,8,7,2 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1628720-66:
(9*1)+(8*6)+(7*2)+(6*8)+(5*7)+(4*2)+(3*0)+(2*6)+(1*6)=180
180 % 10 = 0
So 1628720-66-0 is a valid CAS Registry Number.
1628720-66-0Relevant academic research and scientific papers
Lattuada, Luciano,Argese, Maria,Boi, Valeria,Galimberti, Laura,Gazzetto, Sonia
, p. 1175 - 1180 (2014)
An efficient and scalable preparation of the thyroid hormone analogue O-[3-iodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt (T3-sulfate, 1) is reported. The synthesis involved monoiodination of O-(4-hydroxyphenyl)-3,5-diiodo- L-tyrosineto give liothyronine (2) which was sulfated with chlorosulfonic acid in N,N -dimethylacetamide. Crude T3-sulfate was initially purified by chromatography on polystyrene resin Amberlite XAD 1600 and then crystallized with ethanol. This strategy was scaled-up to give a process suitable for the production of kilogram quantities of API, needed to support preclinical and clinical studies.
