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L-Tyrosine, O-(3-chloro-4-hydroxyphenyl)-3,5-diiodo- is a complex organic compound with the chemical formula C15H12ClI2NO4. It is a derivative of the amino acid L-tyrosine, which is an essential component for the synthesis of proteins in the human body. This specific compound features a 3-chloro-4-hydroxyphenyl group attached to the oxygen atom of the L-tyrosine molecule, along with two iodine atoms at the 3rd and 5th positions. Due to its unique structure, it has potential applications in various fields, such as pharmaceuticals and chemical research. However, it is important to note that the compound's specific uses, safety, and potential side effects should be thoroughly investigated and understood before any practical application.

4299-63-2

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4299-63-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4299-63-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,9 and 9 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4299-63:
(6*4)+(5*2)+(4*9)+(3*9)+(2*6)+(1*3)=112
112 % 10 = 2
So 4299-63-2 is a valid CAS Registry Number.

4299-63-2Upstream product

4299-63-2Relevant academic research and scientific papers

Process development and scale-up of T3-Sulfate, a new prodrug alternative to the conventional hormone therapy of hypothyroidism

Lattuada, Luciano,Argese, Maria,Boi, Valeria,Galimberti, Laura,Gazzetto, Sonia

, p. 1175 - 1180 (2014/12/10)

An efficient and scalable preparation of the thyroid hormone analogue O-[3-iodo-4-(sulfooxy)phenyl]-3,5-diiodo-L-tyrosine sodium salt (T3-sulfate, 1) is reported. The synthesis involved monoiodination of O-(4-hydroxyphenyl)-3,5-diiodo- L-tyrosineto give liothyronine (2) which was sulfated with chlorosulfonic acid in N,N -dimethylacetamide. Crude T3-sulfate was initially purified by chromatography on polystyrene resin Amberlite XAD 1600 and then crystallized with ethanol. This strategy was scaled-up to give a process suitable for the production of kilogram quantities of API, needed to support preclinical and clinical studies.

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