1628946-75-7

Upstream product

• 1126-76-7 1,2-Epoxy-4-phenylbutane 
• 1628946-71-3 PhSO(N-tert-butyldimethylsilyl)CF₂H 
• 1333375-53-3 (difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1628946-73-5 C₁₁H₁₄F₂O 
• 104501-79-3 1,1-Difluoro-5-phenyl-pent-1-en-3-ol 
• 1628946-76-8 C₂₆H₄₁F₂NO₂SSi₂ 

Relevant academic research and scientific papers

Nucleophilic difluoromethylation of epoxides with PhSO(NTBS)CF2H by a preorganization strategy

Unlike the facile synthesis of β-monofluoromethyl alcohols by nucleophilic monofluoromethylation of epoxides, the synthesis of β-difluoromethyl alcohols by nucleophilic difluoromethylation of epoxides still remains a challenge. Herein, studies on tackling this problem with PhSO(NTBS)CF2H (2; TBS=tert-butyldimethylsilyl) are reported. The preorganization of 2 and epoxides with BF3Et2O was found to be crucial for the reaction. The reaction shows excellent regioselectivity and has a broad substrate scope. The facile transformation of the ring-opened products to β-difluoromethyl, γ-difluoromethyl, and β-difluoromethylenyl alcohols demonstrates the synthetic utility of the reaction.