1628946-71-3

Upstream product

• 1333375-53-3 (difluoromethyl)(imino)(phenyl)-λ⁶-sulfanone 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1628946-75-7 C₂₃H₃₃F₂NO₂SSi 
• 1628946-95-1 C₁₀H₁₃F₂NO₂S 
• 1628946-98-4 C₁₁H₁₅F₂NO₂S 

Relevant academic research and scientific papers

Nucleophilic difluoromethylation of epoxides with PhSO(NTBS)CF2H by a preorganization strategy

Unlike the facile synthesis of β-monofluoromethyl alcohols by nucleophilic monofluoromethylation of epoxides, the synthesis of β-difluoromethyl alcohols by nucleophilic difluoromethylation of epoxides still remains a challenge. Herein, studies on tackling this problem with PhSO(NTBS)CF2H (2; TBS=tert-butyldimethylsilyl) are reported. The preorganization of 2 and epoxides with BF3Et2O was found to be crucial for the reaction. The reaction shows excellent regioselectivity and has a broad substrate scope. The facile transformation of the ring-opened products to β-difluoromethyl, γ-difluoromethyl, and β-difluoromethylenyl alcohols demonstrates the synthetic utility of the reaction.