1628958-00-8Relevant academic research and scientific papers
Tandem one-pot synthesis of polysubstituted NH-pyrroles involving the palladium-catalyzed intramolecular oxidative amination of the zinc bromide complex of β-enamino esters
Kim, Ju Hyun,Choi, Suh Young,Bouffard, Jean,Lee, Sang-Gi
, p. 9253 - 9261 (2014/12/11)
The Pd-catalyzed oxidative olefin amination of the zinc bromide complex intermediate, formed by the sequential reaction of nitriles with a Reformatsky reagent and 1-alkynes, affords pyrrole derivatives in good to excellent yields. This tandem protocol pro
Formation of four different aromatic scaffolds from nitriles through tandem divergent catalysis
Kim, Ju Hyun,Bouffard, Jean,Lee, Sang-Gi
supporting information, p. 6435 - 6438 (2014/06/24)
A zinc bromide complex, formed by the sequential reaction of nitriles with a Reformatsky reagent and terminal alkynes, is used as an intermediate for divergent palladium-catalyzed reactions. The reaction pathway of the intermediate is precisely controlled by the choice of the reaction solvent or the palladium catalyst to quickly form four different aromatic scaffolds - arylamines, aminoindenes, pyrroles, and quinolines - starting from readily available nitriles.
