1629-23-8Relevant articles and documents
Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Aertssen, Sjoerd,Amundsen-Isaksen, Enya,Brinch, Shoshy Alam,Damen, Eddy,Galera-Prat, Albert,Krauss, Stefan,Leenders, Ruben G. G.,Murthy, Sudarshan,Nieczypor, Piotr,Smits, Johannes N.,Sowa, Sven T.,Waaler, Jo,Wegert, Anita,Lehti?, Lari,Nazaré, Marc
, p. 17936 - 17949 (2021/12/17)
Tankyrase 1 and 2 (TNKS1/2) catalyze post-translational modification by poly-ADP-ribosylation of a plethora of target proteins. In this function, TNKS1/2 also impact the WNT/β-catenin and Hippo signaling pathways that are involved in numerous human diseas
Palladium-catalyzed C-H cyclization in water: A milder route to 2-arylbenzothiazoles
Inamoto, Kiyofumi,Nozawa, Kanako,Kondo, Yoshinori
supporting information; experimental part, p. 1678 - 1682 (2012/07/17)
Water was successfully employed as a reaction medium in palladium-catalyzed C-H cyclization of thiobenzanilides. Reactions efficiently proceeded under considerably mild conditions such as 40 °C in water, providing a more practical, greener method for the synthesis of 2-arylbenzothiazoles. For some substrates, the addition of an amphiphilic surfactant greatly enhanced the process. The method represents a rare example of palladium-catalyzed C-H functionalization processes performed in water. Georg Thieme Verlag Stuttgart · New York.
One-pot preparation of 2 (alkly)arylbenzothiazoles from the corresponding o-halobenzanilides
Bernardi, Dan,Ba, Lalla A?cha,Kirsch, Gilbert
, p. 2121 - 2123 (2008/02/09)
Thionation of o-halobenzanilides was carried out in the presence of Lawesson's reagent. Subsequently, the formed thioamides reacted with cesium carbonate to give the corresponding benzothiazole derivatives in the same pot. Georg Thieme Verlag Stuttgart.
