1629-95-4

Usage

Uses

Used in Organic Synthesis:
2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE is used as a reagent in organic synthesis for its ability to facilitate the formation of complex organic molecules, contributing to the development of new chemical entities.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE is utilized as an intermediate, playing a crucial role in the synthesis of various medicinal compounds, thereby aiding in the advancement of healthcare solutions.
Used in Agrochemicals:
2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE is employed as an intermediate in the production of agrochemicals, helping to create effective solutions for agricultural applications, such as pesticides and herbicides.
Used as a Catalyst in Chemical Reactions:
2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE is also used as a catalyst to accelerate certain chemical reactions, enhancing the efficiency and speed of industrial processes.
Used in Dyes and Pigments Manufacturing:
2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE is incorporated as a component in the manufacturing of dyes and pigments, contributing to the coloration and stability of various products in the textile, paint, and plastics industries.
Safety Considerations:
It is important to handle 2-AMINO-5,5-DIMETHYL-5,6-DIHYDROBENZOTHIAZOL-7(4H)-ONE with care due to its classification as a mild irritant. Adequate precautions should be taken to prevent skin and eye contact during its use in various applications.

InChI:InChI=1/C9H12N2OS/c1-9(2)3-5-7(6(12)4-9)13-8(10)11-5/h3-4H2,1-2H3,(H2,10,11)

Upstream product

• 37722-34-2 2-bromo-5,5-dimethyl-3-hydroxycyclohex-2-en-1-one 
• 17356-08-0 thiourea 
• 126-81-8 dimedone 
• 1195-91-1 2-bromodimedone 
• 35024-12-5 (4,4-dimethyl-2,6-dioxo-cyclohexyl)-phenyl-iodonium betaine 
• 91054-89-6 2-(4,4-dimethyl-2,6-dioxo-cyclohexyl)-isothiourea; hydrochloride 

Downstream Products

• 92491-27-5 2-Acetamido-5,5-dimethyl-4,5,6,7-tetrahydrobenzo-7-thiazolone 
• 123973-48-8 2-Amino-5,5-dimethyl-5,6,7,8-tetrahydro-4H-thiazolo<5.4-c>-azepin-8-one 
• 10513-25-4 2-chloro-5,5-dimethyl-4,5,6,7-tetrahydrobenzothiazol-7-one 
• 10513-26-5 2-bromo-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one 
• 15090-92-3 2-phenylamino-5,5-dimethyl-4,5,6,7-tetrahydrobenzothiazol-7-one 
• 15091-04-0 2-(morpholin-4-yl)-5,5-dimethyl-4,5,6,7-tetrahydrobenzothiazol-7-one 
• 30837-43-5 2-(4-hydroxy-phenylazo)-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one 
• 68695-96-5 2-(4-diethylamino-phenylazo)-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one 
• 57777-36-3 2-(4-bromophenyl)-6,6-dimethyl-6,7-dihydrobenzo[d]imidazo[2,1-b]thiazol-8(5H)-one 
• 25752-12-9 6,6-Dimethyl-2-phenyl-5,7-dihydroimidazo<2,1-b>benzothiazol-8-one 
• 57777-35-2 6,6-dimethyl-2-(4-nitro-phenyl)-6,7-dihydro-5H-benzo[d]imidazo[2,1-b]thiazol-8-one 

Relevant academic research and scientific papers

Synthesis of thiazoles from the reaction of phenyliodonium ylids of cyclic β-dicarbonyl compounds with thioureas

Phenyliodonium ylids of cyclic β-dicarbonyl compounds react with substituted thioureas to form the corresponding thiouronium ylids. The latter, when they have one free amino group, are converted upon heating to fused thiazoles. The reaction can be considered as a modification of the Hantzsch synthesis.

Synthesis of novel derivatives of 7,8-dihydro-6H-imidazo[2,1-b][1,3]benzothiazol-5-one and their virus-inhibiting activity against influenza A virus

Influenza remains a highly pathogenic and hardly controlled human infection. The ability of selecting drug-resistant variants necessitates the search and development of novel anti-influenza drugs. Herein, we describe the synthesis and evaluation of a seri

Visible Light-Mediated Coupling of Thioureas and 1,3-Dicarbonyls: Towards a Leaving Group-Free Synthesis of Aminothiazoles

A synthesis of aminothiazoles from various 1,3-dicarbonyls and thioureas without a leaving group has been developed. The reaction is photocatalyzed by tetraiodofluorescein, an organic dye. Under irradiation with green LEDs, a sulfur radical is generated in situ from thiourea, followed by addition to the enol tautomer, forming the aminothiazole backbone. This novel strategy provides a greener alternative to the traditional leaving group protocols, with excellent atom economy. (Figure presented.).

THIA-TRIAZA-AS-INDACENES AS PI3-KINASES INHIBITORS FOR THE TREATMENT OF CANCER

The present invention encompasses compounds of general formula (1) wherein R1 to R3 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the

4-(1,3-Thiazol-2-yl)morpholine derivatives as inhibitors of phosphoinositide 3-kinase

4-(1,3-Thiazol-2-yl)morpholine derivatives have been identified as potent and selective inhibitors of phosphoinositide 3-kinase. The SAR data of selected examples are presented and the in vivo profiling of compound 18 is shown to demonstrate the utility of this class of compounds in xenograft models of tumor growth.

FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS

A series of 5,5-dimethyl-5,6-dihydro-1,3-benzothiazol-7(4H)-one and 7,7-dimethyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[5,4-c]azepin-4-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted benzofused mor

Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines

The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed.

FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS

A series of 5,6-dihydro-l,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of b.enefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Synthesis of fused heterocyclic compounds

Dimedone (I) on condensation with acetone and methyl ethyl ketone in the presence of triethylamine affords the pyrano compounds IIa and IIb, respectively.However, it reacts with thiourea in the presence of N-bromosuccinimide and benzoyl peroxide to give t