16290-93-0

Usage

Uses

Used in Pharmaceutical Industry:
2(1H)-Pyrimidinone, 5-methoxy(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Research and Development:
2(1H)-Pyrimidinone, 5-methoxy(9CI) is used as a research compound in the field of medicinal chemistry. It can be utilized to study the structure-activity relationships of pyrimidinone derivatives and their potential applications in drug discovery.
Used in Chemical Synthesis:
2(1H)-Pyrimidinone, 5-methoxy(9CI) can be used as a building block in the synthesis of more complex organic molecules. Its versatile structure allows for further functionalization and modification, making it a valuable component in the creation of novel chemical entities.

Upstream product

• 57-13-6 urea 
• 87026-45-7 4-Chloro-5-methoxy-2-methylthiopyrimidine 
• 28340-76-3 5-Methoxy-2-methylthiopyrimidine 
• 1671-08-5 5-Methoxy-2-methylthiopyrimidin-4(3H)-one 
• 651-06-9 sulfameter 
• 1671-09-6 2-methanesulfonyl-5-methoxypyrimidine 

Relevant academic research and scientific papers

RAF INHIBITOR COMPOUNDS AND METHODS OF USE THEREOF

Compounds of Formulas (I), (IIA) and (IIIA) are useful for inhibiting Raf kinase and for treating disorders mediated thereby. Methods of using compounds of Formulas (I), (IIA) and (IIIA) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

Phenylation of pyrimidinones using diphenyliodonium salts

Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied. The Royal Society of Chemistry 1999.

The use of high pressure liquid chromatography in stability studies of sulfonamides. 3. Sulfamethoxydiazine. Isolation and identification of hydrolytic decomposition products

The stability of sulphamethoxydiazine (1) in HCl (1 mol/l) under elevated temperature was investigated. Isolated decomposition products further served as standards for the selection of HPLC conditions. Three types of stationary phases were tested: Pragosil 5, MicroPak CN-10, MicroPak CH-10. The selection of mobile phases was made in such a way as to be able to inject 1 hydrolysate in HCl (1 mol/l) directly or after simple dilution. Detection was performed with an UV detector at the wavelength of 226 nm. A column packed with MicroPak CN-10 was selected to investigate the process of 1 decomposition. The method made it possible to quantify 1 in the course of hydrolysis and to illustrate the process of decomposition. On the basis of continuous examination of the development of decomposition products during the stability study it was possible to consider the chemism of the decomposition reaction.