87026-45-7

Basic information

• Product Name: 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE
• Synonyms: 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE;4-Chloro-5-methoxy-2-(methylthio)pyrimidine ,97%;4-Chloro-5-methoxy-2-(methylthio)pyrimidine;4-Chloro-5-methoxy-2-(methylthio)
• CAS NO: 87026-45-7
• Molecular Formula: C₆H₇ClN₂OS
• Molecular Weight: 190.65
• Mol File: 87026-45-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 73-77°
• Boiling Point: 285.5 °C at 760 mmHg
• Flash Point: 126.5 °C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 0.0048mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.39±0.29(Predicted)
• CAS DataBase Reference: 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE(87026-45-7)
• EPA Substance Registry System: 4-CHLORO-5-METHOXY-2-(METHYLSULFANYL)PYRIMIDINE(87026-45-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 87026-45-7(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H7ClN2OS/c1-10-4-3-8-6(11-2)9-5(4)7/h3H,1-2H3

Upstream product

• 1671-08-5 5-Methoxy-2-methylthiopyrimidin-4(3H)-one 
• 1671-08-5 5-Methoxy-2-methylthiopyrimidin-4(3H)-one 

Downstream Products

• 16290-93-0 2-Hydroxy-5-methoxypyrimidin 
• 28340-76-3 5-Methoxy-2-methylthiopyrimidine 

Relevant articles and documents

Synthesis and antitumor activity of novel N-benzoyl-N'-substituted pyrimidinyl (thio)semicarbazide derivatives

A series of substituted pyrimidinyl (thio)semicarbazide derivatives were designed and synthesized. The antitumor results showed that the activity of thiosemicarbazide compounds (series II) was generally higher than that of the corresponding semicarbazide derivatives (series I). Among them, IIk displayed higher cytotoxicity against HL-60, BGC-823 and Bel-7402 than that of adriamycin and exhibited broad in vitro cytotoxicity against 13 human tumor cell lines. Meanwhile, the cytotoxic selectivity and anti-multidrug resistance were evaluated, and IIk exhibited selective cytotoxicity against cancer cells in comparison to human normal cells and had significant anti-multidrug resistance capability. The bioassay results showed that IIk showed great promise as a potent lead compound for further antitumor discovery.

TRISUBSTITUTED AMINE COMPOUND

The present invention relates to a compound of the general formula (1): wherein, Y is a methylene group, and the like; A is an optionally substituted heterocyclic group, and the like; B is an optionally substituted heterocyclic group, and the like; R1 is an optionally substituted alkyl group, wherein the alkyl group further may optionally be substituted by an optionally substituted homocyclic group, and the like; and R2 is an optionally substituted amino group, and the like; or a pharmaceutically acceptable derivative thereof, which has an inhibitory activity against cholesteryl ester transfer protein (CETP), thereby being useful for prophylaxis and/or treatment of arteriosclerotic diseases, hyperlipemia or dyslipidemia, and the like.

Phenylation of pyrimidinones using diphenyliodonium salts

Pyrimidinones 1 have been phenylated under basic conditions using diphenyliodonium salts, and the effect of substituents on the yield and regiochemistry has been studied. The Royal Society of Chemistry 1999.